EARLY FUNCTIONAL & STRUCTURAL REPAIR IN MACAQUE STRABISMUS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的长期目标是揭示解释婴儿斜视(眼睛错位)每种行为缺陷的神经机制，以及它们发生的发育时间。该项目的具体目标是确定关键期早期的眼睛重排是否可以修复由婴儿斜视引起的视觉皮质的行为和结构缺陷。本项目是华盛顿大学(密苏里州圣路易斯华盛顿大学PI L.Tychsen博士)R01的分包合同。新生的猕猴是戴着布拉德利·S博士为幼猴设计的护目镜饲养的，这种护目镜装有棱镜来诱导光学斜视。斜视在出生后3周、3个月、6个月进行修复；对应于儿童的极早期(人类：3个月大)、平均(人类：12个月大)和晚期(人类：2岁)斜视手术。在这种准备过程中，斜视的修复包括摘除棱镜护目镜的简单动作。为这个项目产生的具体假设都有一个共同的预测，即眼睛越早调整，视觉功能的恢复就越大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long term goal of this research is to reveal the neural mechanisms that explain each of the behavioral deficits of infantile strabismus (eye misalignment), and the time in development at which they occur. The specific goal of the project is to determine if eye realignment early in the critical period can repair the behavioral and structural deficits of the visual cortex that result from infantile strabismus. The present project is a subcontract to an R01 from Washington University (Dr. L. Tychsen, PI at Washington University, St. Louis MO). Newborn macaques are reared wearing Dr. Bradley¿s goggles that were designed for young monkeys, and which are fitted with prism lenses to induce optical strabismus. The strabismus is ¿repaired¿ at one of three postnatal ages: 3 weeks, 3 months, 6 months; corresponding to ¿very early¿ (humans: 3 months of age), ¿average¿ (humans: 12 months of age), and ¿late¿ (humans: 2 years of age) strabismus surgery in children. In this preparation, repair of strabismus consists of the simple act of the removal of the prism goggles. The specific hypotheses generated for this project have in common the prediction that the earlier the realignment of the eyes, the greater the recovery of visual function.