TAILORING ENRICHMENT TO REARING AND RESEARCH

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目包括几项与非人灵长类动物群落管理有关的研究，这些研究与全面环境富集计划的发展有关。为了继续改进研究设施中灵长类动物的护理，有必要更好地确定富集技术应如何适应生物医学研究中使用的灵长类动物的管理。生物医学研究可能需要限制可用于研究动物的富集技术类型，同时可能改变动物的心理需求。拟议项目将为恒河猴（Macaca mulatta）的福祉和管理提供直接利益。重点将放在三个方面的管理，可能会有很大的变化与饲养和研究用途：：（1）社会分组，包括将圈养在一起的猴子与通过渗透屏障相互作用的猴子进行比较，（2）人类相互作用作为单独圈养猴子的一种丰富形式，以及（3）对持续心理困扰的个体的治疗，包括社会化，人际互动和药物干预。该项目是灵长类动物行为学家和兽医之间的合作努力。行为和生理依赖措施被用作幸福的指标，包括正常和异常行为，健康评估，临床治疗记录和皮质醇浓度。非参数和参数统计被用来分析数据。拟议的研究利用了一个独特的机会，记录改变环境增强的影响，以保持改善行为管理，并衡量各种结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project includes several studies relevant to the management of nonhuman primate colonies in relation to development of a comprehensive environmental enrichment program. In order to continue progress in refining the care of primates in research facilities, it is necessary to better determine how enrichment techniques should be tailored to the management of primates used in biomedical research. Biomedical studies may require restrictions on the type of enrichment techniques that can be implemented for study animals, and may at the same time alter the psychological needs of the animals. The proposed project will provide direct benefit to the well-being and management of rhesus macaques (Macaca mulatta). Focus will be placed on three aspects of management that may vary considerably with rearing and research use: (1) social grouping including a comparison of monkeys housed together with those housed such that they interact through a permeated barrier, (2) human interaction as a form of enrichment for singly housed monkeys, and (3) the treatment of individuals in persistent psychological distress, including socialization, human interaction, and a medication as interventions. The project is a collaborative effort between primate behaviorists and veterinarians. Behavioral and physiological dependent measures are employed as indicators of well-being, including normal and abnormal behavior, health assessments, clinical treatment records, and cortisol concentrations. Nonparametric and parametric statistics are employed to analyze data. The proposed study takes advantage of a unique opportunity to document the effects of altering environmental enhancement in keeping with improved behavioral management, and measuring a variety of outcomes.