COBRE: UND: AUGMENTATION OF IMAGING CORE FACILITY

描述（由申请人提供）：本提案旨在在北达科他州大学建立一个关于神经退行性疾病病理生理学的生物医学研究卓越中心（COBRE）。该中心的总体目标是表征导致神经元变性的细胞机制。拟议的中心将包括五个项目，涉及6名初级教员，每个项目都将研究神经退行性过程的一个独特方面。这五个项目，连同拟议的核心设施，教师招聘和行政核心将极大地帮助我们实现我们的长期目标：发展一个高度互动和协作的研究小组，专注于了解神经退行性疾病的病因，并开发治疗方法来预防或停止神经病理学。该COBRE的具体目标是：1。为COBRE项目主任开发成功的独立研究项目，使他们能够获得校外R01研究赠款。2.）的情况。通过发展核心设施来支持所有研究人员，以加强北达科他州医学与健康科学学院（UNDSMHS）的研究基础设施。3.）第三章通过招聘一名资深神经科学家和四名初级教员到UNDSMHS，扩大神经科学领域的生物医学教师研究，他们的研究是我们COBRE的主题。这些新招聘的教师将在UNDSMHS建立一个研究人员的临界质量，他们的研究专长领域是神经科学的补充领域。4.）在北达科他州大学建立一个国内和国际公认的神经科学研究卓越中心。COBRE特定目标的成功完成将在UNDSMHS建立作为神经科学研究卓越中心的声誉，吸引对神经科学研究感兴趣的教师，博士后研究员和研究生。然后，我们的中心将在获得培训赠款，计划项目赠款和中心赠款方面具有很强的竞争力，这些补助金将使神经科学研究卓越中心能够继续获得COBRE奖。

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on the Pathophysiology of neurodegenerative diseases at the University of North Dakota. The overall objective of this Center is to characterize the cellular mechanisms that contribute to neuronal degeneration. The proposed Center will consist of five projects involving 6 junior faculty members, each of which examines a unique aspect of the neurodegenerative process. These five projects, together with the proposed core facilities, faculty recruitments and administrative core will greatly assist us in meeting our long term goal: To develop a highly interactive and collaborative research group focused on understanding the etiology of neurodegeneration and developing therapeutic approaches to prevent or halt neuropathology. The Specific Aims of this COBRE are: 1.) To develop successful independent research projects for the COBRE project directors that will enable them to obtain extramural R01 research grants. 2.) To enhance research infrastructure at the University of North Dakota School of Medicine & Health Sciences (UNDSMHS) through the development of core facilities to support all investigators. 3.) To expand biomedical faculty research in the area of neuroscience through the recruitment of an established senior level neuroscientist and four junior faculty members to UNDSMHS whose research is in the theme of our COBRE. These new faculty recruits will establish a critical mass of researchers at UNDSMHS whose areas of research expertise are in complimentary areas of neuroscience. 4.) To establish a nationally and internationally recognized Center of Neuroscience Research Excellence at the University of North Dakota. The successful completion of COBRE Specific Aims will establish a reputation at UNDSMHS as a Center of Neuroscience Research Excellence that will attract faculty, postdoctoral fellows, and graduate students interested in neuroscience research. Our Center will then be highly competitive for obtaining training grants, program project grants and center grants that will allow for the continuation of the Center of Neuroscience Research Excellence beyond the COBRE award.