To be confirmed after the rotation year

T细胞免疫反应的产生与线粒体功能密切相关，线粒体功能支持细胞能量的增加和特殊分子的产生。铁是线粒体内产生和利用的催化分子的关键成分。铁缺乏会导致T细胞反应受损，而超负荷则会导致细胞死亡。到目前为止，人们对T细胞中铁代谢和线粒体功能的相互作用知之甚少。该项目的目的是确定铁摄取、细胞内存储和释放在维持线粒体健康支持T细胞功能和分化中的作用。

The generation of a T-cell immune response is tightly linked to mitochondrial functionsupporting increased cellular energy and specialised molecule production. Iron is a keycomponent of catalytic molecules produced and utilised within the mitochondria. Irondeficiency leads to an impaired T-cell response, while an overload can lead to celldeath. So far, very little is known about the interplay of iron metabolism andmitochondrial function in T-cells. The aim of this project is to define the role of ironuptake, intracellular storage and release in maintaining mitochondrial health tosupport T-cell function and differentiation.