To be confirmed after rotation year

转移RNAs(Transfer RNAs，tRNAs)是将遗传信息转化为蛋白质所必需的，其丰度在转录水平和稳定性水平上受到动态调节。TRNA的功能进一步受到大量转录后化学修饰的影响，这些修饰调节翻译效率和保真度。RNA丰度的改变和修饰都与衰老和疾病有关，然而，直到最近，还没有准确的方法来定量tRNA。该项目将通过应用一种新开发的tRNA图谱技术来比较年轻和老年的人和鼠组织，从而识别新的衰老机制，随后的功能特征将为“生物”衰老带来洞察。

Transfer RNAs (tRNAs) are essential for translating genetic information into proteins.The abundance of specific tRNAs is dynamically regulated at the level of transcriptionand stability. tRNA function is further influenced by a multitude of post-transcriptionalchemical modifications that regulate translation efficiency and fidelity. Alterations intRNA abundance and modifications are implicated in both ageing and disease.However, until recently, no accurate approach existed for quantifying tRNAs. Thisproject will identify novel ageing mechanisms by applying a newly developed tRNAprofiling technology to compare young versus old human and mouse tissues, withsubsequent functional characterisation bringing insights to 'biological' ageing.