KY COBRE: IMAGING CORE

描述(由申请人提供)： 人类疾病分子基础生物医学研究卓越中心(COBREMBHD)的目标是通过发展一个专注于在分子水平上了解人类疾病的研究中心，提高肯塔基大学有前途的初级研究人员竞争NIH资助的成功。我们会透过以下途径达致这个目标： (1)召集一批知名的外部资助科学家，他们将担任初级教员的导师，担任研究项目的主要研究人员。(2)为这些初级教员提供与研究人类疾病有关的概念和技术方面的最新培训，重点是将结构生物学应用于这些项目；(3)建立指导计划，包括将里程碑作为发展计划的基础；(4)发展和支持共享的核心设施；(5)为补充初级教员的项目提供试点补助金；(6)提供研讨会计划，强调在分子水平上研究人类疾病的最新进展，结构生物学技术及其在生物医学研究中的应用；(6)举行年度静修，以评估和批评初级教员的进步；(7)聘请有前途的新教员，培养一批在研究人类疾病的分子方面富有成效的研究人员。 五名终身教职助理教授将担任概念和方法重叠的研究项目的个人助理。参加Cobre的初级调查人员来自出色的博士后经验，很可能从培训计划中受益。他们的项目将一种或多种结构生物学技术应用于与人类疾病相关的研究，并有很高的可能性发展为成功的RO1类型的研究拨款。

DESCRIPTION (provided by applicant): The objective of the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease (COBREMBHD) is to enhance the success of promising junior investigators at the University of Kentucky for competing for NIH grant support through the development of a research center focusing on understanding human disease at the molecular level. We will achieve this objective by: (1) assembling a group of established extramurally funded scientists who will serve as mentors for junior faculty serving as principal investigators on research projects. (2) providing these junior faculty with state-of-the-art training in concepts and techniques relevant to studying human disease with an emphasis on the application of structural biology to these projects, (3) establishing mentoring plans including milestones as the basis of the development program, (4) developing and supporting shared core facilities, (5) providing pilot grants for projects that will complement those of the junior faculty, (6) providing a seminar program stressing the latest advances in studying human diseases at the molecular level and techniques of structural biology and their application to biomedical research, (6) holding an annual retreat to evaluate and critique the progress of the junior faculty and (7) hiring promising new faculty to develop a critical mass of productive investigators in studying molecular aspects of human disease. Five tenure track Assistant Professors will serve as PIs on research projects that overlap in concepts and methodology. The junior investigators participating in the COBRE came from excellent postdoctoral experiences and are likely to benefit from the training program. Their projects apply one or more of the techniques of structural biology to studies related to human disease and have a high likelihood of developing into successful RO1 type research grants.