OK COBRE: NUCLEIC ACID ANALYSIS CORE

描述（由申请人提供）：俄克拉荷马州医学研究基金会（OMRF）在此为“自身免疫的分子机制和遗传学”的生物医学研究卓越中心（COBRE）提供一个站点。免疫学和风湿病的研究项目是在20多年前在OMRF开始的，并且从那以后一直在稳步发展。该学院负责许多开创性的发现，并使其成为OMRF的卓越研究领域，并在此基础上建立了这个COBRE。我们推荐四名在自身免疫的遗传学和分子机制方面具有良好前景的生物医学研究生产力的初级研究员。事实上，他们的项目应该对我们理解重要的自身免疫性疾病问题产生重要影响。这些初级研究人员得到了8位杰出导师的支持，他们将提供指导和倡导，这对启动独立科学家的成功职业生涯非常重要。初级研究员提出的项目也将由核酸分析核心和数据分析核心促进，这两个核心都由经验丰富和知识渊博的工作人员科学家指导。事实上，这些核心将有助于有效和经济地将最先进的技术和方法应用于初级调查员执行的项目中正在处理的问题。额外的COBRE初级调查员将被招募到该中心，使其成为许多独立调查员发展的过渡机制，从而维持俄克拉荷马州自身免疫研究中目前取得的卓越水平。COBRE的协同作用、合作和直接努力将为人类自身免疫性疾病提供更深层次的理解，并将促进一支强大的初级调查员团队的独立职业发展。

DESCRIPTION (provided by applicant):The Oklahoma Medical Research Foundation (OMRF) herein proposes a site for a Center for Biomedical Research Excellence (COBRE) on "Molecular Mechanisms and Genetics of Autoimmunity." Research programs in immunology and rheumatic diseases were initiated over 20 years ago at the OMRF and have been steadily growing since. The faculty is responsible for a number of seminal discoveries and has made this an area of research excellence at the OMRF upon which to build this COBRE. We propose four Junior Investigators who have promising futures for biomedical research productivity in the genetics and molecular mechanisms of autoimmunity. Indeed, their projects should have an important impact upon our understanding of important autoimmune disease problems. These Junior Investigators are supported by eight exceptional Mentors, who will provide the guidance and advocacy so important for launching the successful careers of independent scientists. The projects proposed by the Junior Investigators will also be facilitated by a Nucleic Acid Analysis Core and a Data Analysis Core, both of which are directed by very experienced and knowledgeable staff scientists. Indeed, these cores will help efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed in the projects performed by the Junior Investigators. Additional COBRE Junior Investigators will be recruited to this center making this a transitional mechanism for the development of many independent investigators, thereby sustaining the level of excellence now achieved in research into autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.