3D bioprinting nanofibre-reinforced vascular branches

缺乏血管化是生物打印功能器官的主要瓶颈。该项目将通过使用同轴挤出生物打印来开发具有不同内径的血管分支。所制造的水凝胶将用静电纺丝纳米纤维增强。将电纺纳米纤维整合到水凝胶中可以合成具有可调机械性能的材料。纳米纤维的掺入可以通过在结构上电纺或通过将电纺纤维混合到水凝胶中来进行。形态学，机械性能的分支，长期的细胞活力，和封装的细胞的功能将进行研究。

The lack of vascularisation is the main bottleneck of bioprinting functional organs. This project will develop vascular branches with varying inner diameters by using co-axial extrusion bioprinting. The fabricated hydrogels will be reinforced with electrospun nanofibres. Integrating electrospun nanofibres into hydrogels can synthesise materials with tuneable mechanical properties. Incorporation of nanofibres can be performed by electrospinning on the structure or by mixing electrospun fibres into the hydrogel. The morphology, the mechanical properties of the branches, the long-term cell viability, and the function of the encapsulated cells will be investigated.