Genetic Basis of Valvular Heart Disease

心脏瓣膜病是心力衰竭的常见原因。识别心脏瓣膜病的遗传原因对于我们理解这些心脏疾病以及将这些基因发现转化为高危家庭中更好的诊断和预防策略具有重要意义。这项研究计划寻求对患有两种最常见的瓣膜心脏病--二尖瓣脱垂和先天性二尖瓣主动脉瓣--的个人和家庭进行全面的临床和遗传学调查。

Valvular heart disease is a common cause of heart failure. Identification of the genetic causes of valvular heart disease has important implications in our understanding of these heart diseases, as well as translating these genetic discoveries into better diagnostic and prevention strategies in at-risk families. This research proposal seeks to perform a comprehensive clinical and genetic investigation of individuals and families with the two most common valvular heart diseases, mitral valve prolapse and congenital bicuspid aortic valve.