NICHD Cooperative Multicenter Neonatal Research Network

杜克大学医学院新生儿科热情地提交了这份报告。 继续参与NICHD申办的合作多中心研究的更新申请 新生儿研究网络。NRN的目的是研究治疗策略， 通过大型多中心协作试验护理新生儿。该司对NRN的承诺 研究反映在其参与研究，招募和随访患者， 提交和NRN接受涉及五个杜克学院的项目。这些研究包括 与其他杜克研究人员在传染病，真菌学，普拉特学院 工程和人类遗传学中心。这些研究包括： 数据库和链接数据库;新生儿丝虫病的早期诊断;婴儿APOE患病率 围产期失语、脑室内出血和胃食管反流：新生儿 网络实践。杜克参加了以下网络试验：光疗;身体降温 围产期窒息;支持; PCV-7免疫原性;基准干预，以增加 极低出生体重儿发病率和死亡率调查 婴儿; aEEG预测缺氧缺血性脑病预后;肌醇和预防 ROP Pilot和细胞因子研究。在加入网络之前，杜克大学的教师参加了 NICHD赞助的高频振荡试验和iNO用于预防Premies中的BPD;以及 行业赞助的针对肺动脉高压足月婴儿的CINRGI iNO研究， 头部冷却用于围产期窒息研究。新生儿-围产期医学部是 致力于临床研究，并得到了医学院的支持，这一点可以从其收到的 杜克转化医学奖我们的承诺和专业知识的进一步证据是 由教师在NRN谁是硕士（Gotten，埃雷拉）和博士的参与说明 （本杰明）在临床研究和流行病学准备。值得注意的是，杜克新生儿科的病人 在过去一年中，集水面积增长了56%，因此目标是增加 符合NRN研究条件的患者入院率下降25%。该司设有一个全面的 多学科随访诊所，以全面的方式接近患者，并特别关注 到营养。它与社区机构和服务机构合作，并有病人回报。 网络研究和通用数据库的费率为380%。

The Division of Neonatology, Duke University School of Medicine enthusiastically submits this renewal application for continued participation in the NICHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to investigate treatment strategies for the care neonates through large multicenter collaborative trials. The Division's commitment to NRN research is reflected in its participation in studies, recruitment and follow-up of patients, and its submission and NRN acceptance of projects involving five Duke faculty. These studies encompass collaborations with other Duke investigators in Infectious Diseases, Mycology, the Pratt School of Engineering and the Center for Human Genetics. These studies include: The Anonymized DNA Bank and Linked Database; Early Diagnosis of Neonatal Candidiasis; Prevalence of APOE in Infants with Perinatal Asyphxia and Intraventricular Hemorrhage;and Gastroesophageal Reflux: Neonatal Network Practices. Duke has participated in the following Network trials: Phototherapy; Body-Cooling for Perinatal Asphyxia; SUPPORT; PCV-7 Immunogenicity; Benchmarking Intervention to Increase Survival without Bronchopulmonary Dysplasia; the Survey of Morbidity and Mortality among VLBW Infants; aEEG to Predict Outcome after Hypoxic-lschemic Encephalopathy; Inositol and Prevention of ROP Pilot, and the Cytokine Studies. Prior to joining the Network, Duke faculty participated in the NICHD-sponsored High Frequency Oscillation Trial and iNO for Prevention of BPD in Premies; and the industry-sponsored CINRGI iNO Study for Term Infants with Pulmonary Hypertension and Head-Cooling for Perinatal Asphyxia studies. The Division of Neonatal-Perinatal Medicine is committed to clinical research and has the School of Medicine's support as evidenced by its receipt of the Duke Translational Medicine Award. Further evidence of our commitment and expertise is illustrated by the participation of faculty in the NRN who are Masters (Gotten, Herrera) and PhD (Benjamin) prepared in clinical research and epidemiology. Significantly, Duke Neonatology's patient catchment area has grown by 56% in the past year and as a consequence is targeted to increase admissions of patients eligible for NRN studies by 25%. The Division houses a comprehensive multidisciplinary follow-up clinic that approaches the patient in a holistic manner with special attention to nutrition. It works collaboratively with community agencies and services and has a patient return rate for Network studies and the Generic Data Base of3 80%.