Translational Research in Cancer Prevention

描述(由申请者提供)：为一个名为“癌症预防中的转化研究”的科学研讨会申请会议资助。研讨会将于2007年10月14-16日在以色列海法的丹·卡梅尔酒店举行。本次研讨会的组委会由Dean Brenner博士(美国)和Gad Rennert博士(以色列)组成。本次会议的目标是： 1：通过以下方式将致癌机制的新数据应用于转化性癌症预防： A.确定新的干预靶点；b.开发用于癌症预防干预措施有效性监测的生物标记物；c.开发和验证用于癌症早期检测的生物标记物。 2：回顾了解基因-环境相互作用的最新进展，以便： A.开发确定人群和个人癌症风险的新范例；b.将癌症风险与癌症预防干预策略联系起来；3.促进来自美国、中东和欧洲的科学家之间的合作，以开发新的方法来干预乳腺癌和结直肠癌发展的高危对象。 邀请与会者的依据是他们在科学学科方面的多样性、互动和合作的经验和记录，以及他们被认为愿意改变先入为主的观念，以适应新的信息和重新制定未来的研究计划。这次会议气氛紧张，仿效戈登会议。它要求与会者作为一个小组保持隔离三天，密切合作。用餐和空闲时间的安排是为了增加与会者进行非正式互动的机会。会议的特点是30分钟的讲座、频繁的讨论时段、多个30分钟的小组讨论、午餐和晚餐时段，以及集中讨论小组会议的午餐和晚餐时段，以及会议结束时的《白皮书》，以创造闭幕和重点的需要。白皮书和演讲者论文将在经过适当的同行审查后提交《欧洲预防和癌症生物标记物杂志》发表。通过密集的互动，与会者将相互熟悉，将了解会议上代表的不同学科的优势和劣势，并将认识到并建立跨学科互动，以创造必要的科学关键群体来推动该领域的发展。

DESCRIPTION (provided by applicant): Meeting grant support is requested for a scientific workshop entitled, "Translational Research in Cancer Prevention." This workshop will be held at the Dan Carmel Hotel in Haifa, Israel, on October 14-16, 2007. The organizing committee for this workshop consists of Drs. Dean Brenner (USA) and Gad Rennert (Israel). The objectives of this conference are: 1: To apply new data on carcinogenesis mechanisms in translational cancer prevention through: a. Identifying new interventional targets; b. Developing biomarkers for efficacy monitoring of cancer preventive interventions; c. Developing and validating biomarkers for early detection of cancer. 2: To review the state of art in understanding gene-environment interactions in order to: a. Develop new paradigms of define cancer risk in populations and in individuals; b. Link cancer risk to cancer preventive interventional strategies; 3. To promote collaborations among scientists from the United States, the Middle East and Europe to develop novel approaches to intervene in subjects at high risk for the development of breast and colorectal cancer. Conferees are invited based upon their diversity in scientific discipline, interactive and collaborative experience and track-record, and perceived willingness to alter preconceptions in order to accommodate new information and reformulate future research plans. The Conference is intense and modeled after the Gordon Conferences. It requires conferees to remain segregated as a group for three days, working closely together. Meals and free time are structured to enhance the opportunities of conferees to interact informally. The Conference features a 30 minute lectures, frequent discussion periods, multiple 30 minute panel discussions, lunch and dinner periods with focused group meetings, and an end of conference "White Paper" to create the need for closure and focus. The White Papers and speaker papers will be submitted for publication in the European Journal of Prevention and Cancer Biomarkers after appropriate peer review. By intensively interacting, conferees will become familiar with each other, will understand the strengths and weaknesses of the diverse disciplines represented at the meeting, and will recognize and establish cross disciplinary interactions to create necessary scientific critical masses to advance the field.