Prolactin and Growth Hormone Family 2008 Gordon Research Conference

描述(申请人提供)：2008年催乳素和生长激素戈登研究会议将提供一个论坛，介绍和积极讨论关于催乳素、生长激素和相关多肽的最前沿的信息和想法。戈登研究会议的形式将汇集在这些激素配体及其受体的结构、生化、细胞信号、生理、发育和临床病理方面处于国际领先地位的研究人员。我们预计这次会议将对催乳素和生长激素生物学进行全面和深入的报道，从而延续这一领域首屈一指的会议的传统。催乳素和生长激素的多肽配体和受体已被证明分别介导与生殖和生长有关的关键生物学行为。然而，PRL目前已被证明也影响许多非生殖靶点，如调节行为、促进神经发生、诱导肿瘤发生、调节血管生成和骨形成，以及影响免疫系统。同样，生长激素生物学超越了其经典的IGF-1刺激和促进生长的作用。事实上，GH/IGF-1系统与癌症的发生、细胞的维持和修复以及长寿/衰老途径有关。虽然最近的这些进展为PRL和GH的作用提供了重要的见解，但这两种激素调节其影响的确切机制仍然没有答案。我们鼓励对这些领域感兴趣的所有职业阶段的研究人员参加PRL和生长激素GRC。

DESCRIPTION (provided by applicant): The 2008 Prolactin and Growth Hormone Gordon Research Conference will provide a forum for the presentation and active discussion of the most cutting-edge information and ideas on Prolactin, Growth Hormone and related peptides. The Gordon Research Conference format will bring together investigators that are international leaders in the structural, biochemical, cell signaling, physiological, developmental and clinicalpathological aspects of these hormone ligands and their receptors. We expect that this conference will provide a thorough and in-depth coverage of prolactin and growth hormone biology, thus continuing the tradition of this being the premier meeting in this field. The peptide ligands and receptors for PRL and GH have been shown to mediate critical biological actions related to reproduction and growth, respectively. However, PRL has now been documented to also affect many nonreproductive targets, such as modulating behavior, promoting neurogenesis, inducing tumorigenesis, regulating angiogenesis and bone formation, and impacting the immune system. Similarly, GH biology extends beyond its classical IGF-1-stimulatory and growth-promoting effects. Indeed, the GH/IGF-1 system has been implicated in carcinogenesis, cellular maintenance and repair, and longevity/aging pathways. While these recent advances have provided important insights into PRL and GH actions, nevertheless the precise mechanisms by which these two hormones mediate their effects remain unanswered. We encourage investigators at all career stages interested in these areas to attend the PRL and Growth Hormone GRC.