CSHL Course on Yeast Genetics and Genomics

描述(由申请人提供)：冷泉港实验室酵母遗传学和基因组学课程建议继续在培训新使用酿酒酵母进行生物研究的研究人员方面发挥关键作用的悠久传统。最近的标题更改反映出更加重视让参与者熟悉基因组学和蛋白质组学中最新技术的使用。这门为期三周的高强度课程旨在让每个学生精通酵母遗传学的基础，然后为课程进展中所涵盖的更复杂的方法奠定概念上的主干。实验室实验分为12个部分，涵盖各种主题，包括：1.使用酵母的基本原理；2.酵母分子生物学简介；3.遗传和物理相互作用分析；4.基因组学。这门课程的实验部分由讲师每天的理论讲座和世界级的研讨会系列组成，讲师因其在该系统中的成熟专业知识而被选中，并由使用酵母系统的知名研究人员举办一系列世界级研讨会。因此，每个学生都可以接触到他们所教授的方法的基本原理，以及该领域专家对这些方法的最新应用。这门课程有着良好的声誉，并寻求继续服务于不同的生物学家社区，其中包括来自不同背景的科学家，如进化生物学、数量生物学，以及在其他系统中工作的生物学家，鉴于在这种模式生物中可用于功能基因组研究的大量资源，这些系统可以被证明从酵母的利用中获得明显的好处。此外，寻求将酵母菌方法纳入本科课程的教育工作者是该课程的临时学生。虽然这门课程的总体组织每年都保持不变，但随着酵母生物学和基因组学这一广泛领域的变化，课程内容自然发生了变化；随着新教师的更换(每年约1名)，新课程增加了新的专业知识，新教师将最新的技术和方法融入到课程中。由于每年至少保留两名教师，这种演变并不是以牺牲连续性为代价的。

DESCRIPTION (provided by applicant): The Cold Spring Harbor Laboratory Yeast Genetics and Genomics Course proposes to continue with a long tradition of serving a critical role in the training of investigators new to the use of S. cerevisiae for biological research. The recent title change reflects a greater emphasis on familiarizing participants with the use of the latest techniques in genomics and proteomics. This three-week highly intensive course is designed to make each student proficient in the fundamentals of yeast genetics which then establishes the conceptual backbone for the more sophisticated methods that are covered as the course progresses. The laboratory experiments are broken into twelve multi-part sections that cover a variety of topics including: 1. Fundamentals of working with yeast; 2. Introduction to yeast molecular biology; 3. Genetic and physical interaction analysis; and 4. Genomics. The experimental portion of the course is complemented by daily theoretical lectures by the instructors chosen for their proven expertise in the system and a world-class seminar series from renowned investigators that utilize the yeast system. As a result every student is exposed to the underlying principles of the methods they are being taught and their state-of-the-art application by the experts in the field. The course has a well-established reputation for, and seeks to continue, serving a diverse community of biologists that include scientists from disparate backgrounds such as evolutionary biology, quantitative biology, as well as biologists working in other systems that can prove a clear benefit from the utilization of yeast, given the large number of resources available for functional genomic studies in this model organism. In addition, educators that seek to incorporate yeast approaches in undergraduate courses are occasional students in the course. Although the general organization of the course is intended to remain the same from year to year, there is a natural evolution in content as the broad field of yeast biology and genomics changes; as instructors are replaced (~1 per year) new expertise is added to the course and the latest technologies and approaches are incorporated into the curriculum by the new instructors. Since at least two instructors remain from year to year, this evolution does not come at the sacrifice of continuity.