Echo MRI 3-in-1

描述(由申请人提供)：ECHO MRI-100(Tm)3合1肥胖是一个对人类健康影响越来越大的问题，目前美国超过60%的人口坦率地说是肥胖或超重。尽管这一问题普遍存在，但几乎没有有效的治疗方法。小鼠模型为理解在人类肥胖发展中重要的途径提供了有价值的见解。这包括了解分子途径和饮食诱导肥胖的影响。分析老鼠模型需要评估身体成分的技术能力，特别是肥胖症。BIDMC内分泌学分部肥胖症研究人员目前使用的技术有很大的局限性。获得要求的EchoMRI 3合1将绕过这一限制，提高执行研究的能力，并减少所需的队列大小。此外，该设备将提供迄今无法提供的评估组织样本成分的能力，无论是来自啮齿动物的组织样本，还是来自人类活检样本的组织样本。由于设备的容量，除了预计BIDMC内分泌教职员工及其合作者的大量使用外，这项服务还可以提供给BIDMC的其他研究人员。

DESCRIPTION (provided by applicant): Echo MRI-100(tm) 3-in-1 Obesity is a problem with increasing impact on human health and at present more than 60% of the population in the U.S. is either frankly obese or overweight. Despite the prevalence of this problem there are few effective treatments. Mouse models have provided valuable insights into understanding pathways important in the development of human obesity. This includes understanding both molecular pathways and the effects of dietary induced obesity. Analysis of mouse models requires technical capacity to evaluate body composition, particularly adiposity. The technology currently available to the group of obesity researchers at the BIDMC division of Endocrinology has significant limitations. Acquisition of the requested EchoMRI 3-in-1 will bypass this limitation and enhance ability to perform studies and also decrease the size of cohorts required. In addition this equipment will provide a heretofore unavailable capacity to evaluate composition of tissue samples, either from rodents or from human biopsy samples. Because of the capacity of the equipment, in addition to projected significant use by BIDMC Endocrine faculty and their collaborators the service can be offered to other BIDMC investigators.