Chicago Consortium Women's Interagency HIV Study lll

描述（由申请人提供）作为一项多中心、前瞻性队列研究，妇女跨机构艾滋病毒研究（WIHS）旨在直接解决与妇女中艾滋病毒的自然史和临床表现相关的关键假设。在WIHS- iii（12/02-11/07）期间，WIHS的科学目标是：1)开发、完善和评估抗逆转录病毒治疗（ART）暴露的综合措施，并将这些措施与艾滋病毒疾病进展标志物联系起来；2)确定HIV-1感染的治疗史以及对高活性抗逆转录病毒治疗（HAART）的临床、病毒学和免疫反应的个体决定因素，包括宿主和病毒遗传因素；3)评估与抗逆转录病毒治疗相关的不良事件。4)调查艾滋病病毒的长期影响,并使用HMRT,发病率/自然历史引起疾病的病毒交叉感染的女性或艾滋病毒的风险,关注人类乳头状瘤病毒感染,宫颈肿瘤,和丙型肝炎病毒感染和肝疾病,5)评估年龄的影响,排卵的功能、更年期和治疗艾滋病毒感染和对艺术的过程中,6)描述艾滋病毒的流行病学——女性癌症有关,进一步明确接受HAART治疗的女性的恶性肿瘤的自然病史；7)评估HIV疾病的口腔表现。

DESCRIPTION (provided by applicant) As a multicenter, prospective cohort study The Women's Interagency HIV Study (WIHS) is designed to directly address key hypotheses related to the natural history and clinical manifestation of HIV among women. During WIHS-III (12/02-11/07), WIHS scientific Aims are to 1) develop, refine, and evaluate composite measures of antiretroviral therapy (ART) exposure and relate these measures to markers of HIV disease progression, 2) define the treated history of HIV-1 infection and the individual determinants, including host and viral genetic factors, of clinical, virologic and immunologic response to highly-active antiretroviral therapy (HAART), 3) evaluate adverse events associated with ART, 4) investigate the long term effects of HIV, and use of HMRT, on the incidence/natural history of viral co-infections that cause disease in women with or at risk for HIV, focusing on human papillomavirus infection and cervical neoplasia, and hepatitis C virus infection and liver disease, 5) evaluate the effects of age, ovulatory function, menopause and its treatment on the course of HIV infection and response to ART, 6) describe the epidemiology of HIV- associated cancers in women, and further define the natural history of malignancies in women on HAART , and 7) evaluate the oral manifestations of HIV disease. Chicago WIHS will use its nine years of successful retention strategies to engage and retain 390 participants (295 HIV+, 95 HIV-) at four clinical sites including150 participants at the oral site through six month visit cycles. These will include interviews, exams, blood, gynecologic and oral specimens, medical record abstractions, registry matches, and local and centralized laboratory analysis. Chicago WIHS will contribute the highest quality data, lead and participate in epidemiologic analyses, and disseminate the results and scientific information learned from this research initiative. As our site-specific scientific initiative, we will investigate immune recovery in HIV infected women on HMRT with particular interest in the effects of age, drug use, exogenous hormones and menopause on immune recovery.