Research Training in Infections and Immunity

描述(由申请人提供)：这是一项新的NRSA申请，每年支持两名博士后实习生，为期五年。该奖项将大大提高有才华的实习生利用杰出机会在贝勒医学院进行传染病研究培训的能力。目前，贝勒医学院或德克萨斯医学中心内没有NRSA，可以进行非艾滋病感染的临床研究培训。然而，对训练有素的专业人士的需求越来越大，他们能够进行以临床为基础的研究，针对威胁美国公民健康的非艾滋病感染进行治疗和预防，包括传染性胃肠炎和肺炎等古老疾病，以及生物恐怖主义构成的新威胁。贝勒医学院在包括生物防御在内的许多领域都有极好的培训机会。具有良好的联邦资助和培训经验的参与项目包括：1)先天免疫和医院感染；2)寄生虫感染；3)病毒和细菌性胃肠炎；4)病毒致癌；5)急性呼吸道病原体；6)疫苗评估；7)结核病；8)幽门螺杆菌感染；9)假体感染。2002年，对参与这一NRSA计划的特定中心和计划的赠款支持总额为19,769,825美元。感染和免疫研究培训计划的结构将包含三个组成部分，代表受训人员可以进行的一般培训：1)基于实验室的临床研究；2)临床研究试验；3)临床流行病学。所有受训人员将被鼓励参加贝勒医学院的临床科学家培训计划，并获得临床调查硕士学位。那些从事临床流行病学研究的人可以选择德克萨斯大学休斯顿公共卫生学院的公共卫生硕士学位。贝勒医学院的成人传染病培训项目表明，它可以吸引高素质的博士后学员，其中一半是女性，近四分之一的少数民族代表不足，并为他们指明未来传染病临床研究的方向。在过去的两年里，该计划培养出的毕业生成功地完成了拟议的三条培训途径中的每一条。这四个人总共发表了26篇同行评议的原创手稿，并获得了几项享有盛誉的赠款和职业发展奖，总额为1,862,500美元。这一最近的记录被作为支持每年两名博士后实习生的请求的证据。

DESCRIPTION (provided by applicant): This is a new NRSA application to support two postdoctoral trainees per year for five years This award will substantially increase the ability of talented trainees to exploit outstanding opportunities to pursue research training in infectious diseases at Baylor College of Medicine. At this time, no NRSA exists within Baylor College of Medicine or the Texas Medical Center to pursue clinical research training in non-AIDS infections. Yet, there is increasing need for trained professionals capable of performing clinically based research directed at treatment and prevention of non-AIDS infections that threaten the health of US citizens, including age-old scourges such as infectious gastroenteritis and pneumonia and new threats posed by bioterrorism. Superb training opportunities exist at Baylor College of Medicine in a number of areas, including biodefense. Participating projects with a strong record of federal funding and training experience include: 1) Innate Immunity and Nosocomial Infections; 2) Parasitic Infections; 3) Viral and Bacterial Gastroenteritis; 4) Viral Oncogenesis; 5) Acute Respiratory Pathogens; 6) Vaccine Evaluations; 7) Tuberculosis; 8) Helicobacter pylori Infection; and 9) Prostheses Infections. Total grant support in 2002 for the specific centers and programs participating in this NRSA Program is $19,769,825. The structure of the Program for Research Training in Infections and Immunity will contain three components that represent general training tracks that can be pursued by trainees: 1) laboratory-based clinical research; 2) clinical research trials; and 3) clinical epidemiology. All trainees will be encouraged to participate in the Clinical Scientist Training Program at Baylor College of Medicine and obtain their Masters Degree in Clinical Investigation. Those pursuing the clinical epidemiology track may opt for a MPH Degree at the University of Texas-Houston School of Public Health. The Adult Infectious Diseases Training Program at Baylor College of Medicine has shown it can attract highly qualified postdoctoral trainees, half of them women and close to a quarter underrepresented minorities, and point them in the direction of future infectious diseases clinical research. In the past two years, this program has produced graduates who have successfully pursued each of the three training pathways proposed. Altogether, these four individuals have published 26 original peer-reviewed manuscripts and have been awarded several prestigious grants and career development awards, totaling $1,862,500. This recent track record is offered as evidence in support of the request for two postdoctoral trainees per year.