Training Program in Signal Transduction and Cancer

描述（由申请人提供）：本申请是西北大学Robert H. Lurie综合癌症中心信号转导和癌症培训项目（T32 CA070085）的持续资助请求，该中心是nci资助的综合癌症中心。信号转导和癌症培训项目于1997年获得了NCI的资助，并于2002年获得了续期资助。该培训计划汇集了对受体、生长因子和信号转导途径感兴趣的教职员工和博士后，并为信号转导和癌症领域的博士后提供培训。这些受体是由美国国立卫生研究院资助的研究人员建立的，他们属于癌症中心的所有五个基础科学项目：病毒致癌；肿瘤侵袭、转移与血管生成；癌症中的激素和信号转导，癌症基因和分子调控以及癌细胞生物学。项目的凝聚力是通过有组织的会议、期刊俱乐部、研讨会和专题讨论会来实现的。这些活动为分享最新的科学成果和促进智力合作与互动提供了一个结构化的论坛。9年来，培养了24名博士后，其中少数民族博士生3名。除了实验室研究外，学员还需要参加与该计划相关的教育活动（实验室会议、期刊俱乐部、研讨会、专题讨论会）。所有受训者都参加道德研讨会。我们目前正在安排10年级的学生，并在《科学》杂志上刊登了广告，以吸引最优秀的候选人加入该项目。基于我们的期望，我们将保持相同的高素质申请者的候选人才库，我们要求继续资助每年四个博士后职位，为期五年。这将使我们能够继续在罗伯特H. Lurie综合癌症中心进行信号转导和癌症的博士后培训。鉴于癌症是美国第二大死亡原因，我们的信号转导和癌症培训项目与这一重要的公共卫生问题直接相关。

DESCRIPTION (provided by applicant): This application is a request for continued funding of the Training Program in Signal Transduction and Cancer (T32 CA070085) at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, an NCI-funded comprehensive cancer center. The Training Program in Signal Transduction and Cancer received funding from the NCI in 1997 and renewal funding in 2002. The Training Program brings together faculty and postdoctoral fellows with a focused interest in receptors, growth factors and signal transduction pathways and trains postdoctoral fellows for a career in signal transduction and cancer. The preceptors are established NIH funded investigators and they belong to all five basic science programs of the Cancer Center: Viral Oncogenesis; Tumor Invasion, Metastasis and Angiogenesis; Hormones and Signal Transduction in Cancer, Cancer Genes and Molecular Regulation and Cancer Cell Biology. Program cohesion is accomplished through organized meetings, journal clubs and seminars and symposia. These activities provide a structured forum for sharing the latest scientific results and promote intellectual collaborations and interactions. Over the last nine years the Training Program has successfully trained 24 postdoctoral fellows, including three minority trainees. Trainees are required to attend the educational activities (laboratory meetings, journal club, seminars, symposia) associated with the Program in addition to their laboratory research. All trainees enroll in the Ethics Colloquium. We are currently making appointments for Year 10 and advertisements have been placed in the journal Science to attract the best candidates to join the Program. Based on our expectation that we will maintain the same candidate pool of highly qualified applicants we request continued funding for the four postdoctoral positions per year for a period of five years in the present application. This will enable us to continue focused postdoctoral training in Signal Transduction and Cancer at the Robert H. Lurie Comprehensive Cancer Center. In view of the fact that cancer is the second leading cause of death in the U.S., our Training Program in Signal Transduction and Cancer has direct relevance to this important public health issue.