Chemistry-Biology Interface Predoctoral Training Grant

描述（由申请人提供）：在此建议中，我们要求我们的化学-生物学接口（CBI）博士前培训补助金的第二次更新。1995年，我们在马萨诸塞州大学启动了一项新的跨学科培训计划，该计划建立在现有优势的基础上，并正式确立了教师对物理科学和生命科学之间合作的承诺。我们实施了CBI课程，该课程与三个参与研究生课程的要求相吻合，化学，分子与细胞生物学和聚合物科学与工程，但使具有化学或生物学背景的学生能够在补充学科的培训中补充其家庭学科的培训。 在目前的资助期间，我们的CBI培训计划大幅增长：参与部门的数量从3个增加到4个，CBI培训学院的数量从16个增加到19个，最值得注意的是，正式附属学生的数量从14个增加到61个。化学工程的加入建立了我们在定量培训和生物材料方面的优势，并为生物工程增加了新的机会。我们预计我们的CBI计划的持续增长作为额外的部门，特别是物理和计算机科学，进入CBI相关领域。CBI计划目前为六名博士生提供NIH支持，大学比赛支持一名在化学生物学接口工作的研究生。为了继续促进CBI计划的不断增长的实力，因为它扩展到新的学科和培训越来越多的学生，我们要求在第3-5年的补助金期间NIH资助的培训名额的数量适度增加。 我们提供的跨学科培训体现在新的“药物设计”课程的开发，现在是CBI课程的一个组成部分。在这个受欢迎的课程中，学生将获得化学和生物学的背景讲座，使他们形成共同点，然后由制药行业的演讲者每周举办研讨会，向学生介绍化学和生物学的全方位主题，这些主题对于成功设计和开发新药至关重要。通过这种化学和生物学方法和知识框架的培训，我们的CBI毕业生有能力在未来的工作中提出和解决重大的生物医学问题。

DESCRIPTION (provided by applicant): In this proposal, we request a second renewal of our Chemistry-Biology Interface (CBI) Predoctoral Training Grant. In 1995 we launched a new interdisciplinary training program at the University of Massachusetts that built on existing strengths and formalized the faculty's commitment to collaboration between the physical and life sciences. We implemented a CBI curriculum that meshed with the requirements of the three participating graduate programs, Chemistry, Molecular & Cellular Biology, and Polymer Science & Engineering, yet enabled students with either chemical or biological backgrounds to supplement training in their home discipline with training in the complementary discipline. During the current funding period, our CBI Training Program has grown substantially: the number of participating departments has grown from 3 to 4, the number of CBI Training Faculty has grown from 16 to 19 and most notably, the number of formally affiliated students has increased from 14 to 61. The addition of Chemical Engineering builds our strengths in quantitative training and in biomaterials, and adds new opportunities in bioengineering. We anticipate continued growth of our CBI Program as additional departments, notably Physics and Computer Science, move into CBI-related areas. The CBI Program currently provides NIH support for six predoctoral students, and a University match supports one additional graduate student working at the chemistry-biology interface. To continue to foster the growing strength of the CBI program as it expands into new disciplines and trains increasing numbers of students, we request a modest increase in the number of NIH-funded Traineeships in years 3-5 of the of the grant period. The interdisciplinary training we provide is exemplified by the development of a new "Drug Design" course that is now an integral part of the CBI curriculum. In this popular course, students are provided with background lectures in chemistry and biology to bring them to a common ground, followed by weekly seminars by speakers from the pharmaceutical industry to introduce students to the full range of topics in chemistry and biology that are critical for successful design and development of new drugs. With this type of training in the methods and intellectual framework of both chemistry and biology, our CBI graduates are equipped to pose and solve significant biomedical questions in their future work.