Pittsburgh Resuscitation Network

描述(由申请人提供)： 本申请描述了匹兹堡作为临床研究联盟中的区域临床中心(RCC)可以提供的独特资源，以改善复苏结果。匹兹堡已经组建了一个多学科团队，致力于改善心血管稳定性的恢复，并将脑损伤降至最低。独特的资源包括与地区紧急医疗服务机构的牢固工作关系，该地区最繁忙的创伤中心之一，综合医疗保健系统，以及专注于复苏的核心研究人员。我们已经包括了标准化护理、确保协议遵从性和执行详细的功能结果评估的计划。我们有机制控制在实地、急诊科、重症监护病房、康复和功能评估时对受试者的干预。心肺骤停和创伤患者的基线特征适合于临床研究。我们目前每年监测500多名患者的心肺骤停后的复苏情况和结果。我们目前每年治疗3600多名创伤患者。每年有500多名创伤患者的创伤严重程度评分为15或更高，每年约有150名创伤患者使用目前的治疗方法进行致命的创伤损伤。为该联盟提出了两个概念试验。第一个研究将研究(1)单位时间内胸部按压次数的增加和(2)不同诱导低温持续时间对心肺骤停后存活和恢复的影响。第二项研究将考察创伤合并失血性休克后故意诱导亚低温的效果。还描述了临床研究培训核心，目的是培训联盟内的年轻研究人员。

DESCRIPTION (provided by applicant): This application describes the unique resources Pittsburgh can provide as a Regional Clinical Center (RCC) in a Clinical Research Consortium to Improve Resuscitation Outcomes. Pittsburgh has assembled a multidisciplinary team dedicated to improving restoration of cardiovascular stability and minimizing brain injury. Unique resources include a strong working relationship with regional emergency medical services, one of the busiest trauma centers in the region, an integrated health care system, and a core of researchers focused on resuscitation. We have included plans to standardize care, assure protocol compliance, and perform detailed functional outcome assessment. We have mechanisms to control interventions for subjects in the field, in the emergency department, in the intensive care unit, in rehabiliation and at the time of functional evaluation. The baseline characteristics of cardiopulmonary arrest and traumatized patients are suitable for clinical research. We currently monitor the resuscitation and outcomes after cardiopulmonary arrest for over 500 individuals each year. We currently treat over 3600 trauma patients per year. Over 500 trauma patients per year have injury severity scores of 15 or greater, and about 150 trauma patients per year have fatal traumatic injuries using current therapy. Two concept trials are presented for the Consortium. The first will study (1) an increase in the number of chest compressions delivered per unit time and (2) different durations of induced hypothermia on survival and recovery after cardiopulmonary arrest. The second will examine the effect of intentional induction of mild hypothermia after trauma with hemorrhagic shock. A clinical research training core is also described for purposes of training a young investigator within the Consortium.