Rapid Multipathogen Detection For POCT and Natioal Disaster Readiness

核心5.中心的行政管理 领导愿景、中心主题和公共卫生。Kost博士(PI)与美国和泰国 研究小组报告了卡特里娜飓风和2005年海啸的现场调查结果 2006年10月出版的《美国临床病理学杂志》(Kost 2006E)。2006年12月，他的 《医学检验观察家》刊发POCT与备灾教育简报 (KOST 2006F)。观察和认识医生、护士、 救援人员启发了危急-紧急-灾难护理的中心主题。基本上，如果没有 适合或足够的POC和危重护理检测设备，这些世界上的医护人员 灾难被迫实行经验医学，而不是循证医学。PoC 技术研究网可以帮助纠正这种情况！ POCT的环境压力测试几个月前在POCT‘CTR开始。结果 证明POCT试剂不能承受极端温度和其他困难 在救灾过程中遇到的问题(见核心2，“研究进展报告”)。斯蒂芬妮 POCT-CTR研究员Sumner提交了一份摘要(Sumner 2007)，《环境限制 《防灾减灾战略：与备灾工作的相关性》(见附录)，致国际防灾委员会全国会议 美国临床化学协会(AACC)将于2007年7月在圣地亚哥举行。 科斯特博士将主持AACC研讨会并发表演讲，主题为《诊断性医疗保健 危重病护理和灾难准备战略？准备关注点和危重护理 测试：海啸、卡特里娜飓风、地震和DMATS。 疾控中心负责人格伯丁接受了邀请，在他的讲话之前在全体会议上发言 研讨会。 这些“先行先试”举措与多重病原体检测的临床研究 在核心1中描述的支持我们的中心主题危急-紧急-灾难护理。早期工作 还推出了公共使用的PoC设备的环境标准概念 健康。虽然POCT已经发展成更小、更智能、更快、更便宜，但它还不够强大 或在农村、紧急情况和灾难环境中连接(Kost 2006E和2006J)和全血 多重病原体检测滞后于其他领域的进展，如快速索引 多项心脏生物标志物POCT在急性冠脉综合征美国胸痛中的应用 中心(Kost 2005b)。 因此，我们中心的任务是发展完全能够实地开展的业务，包括 病原体检测，具有正确解释、集成和合成的诊断结果 快速医疗诊断、监测和治疗。我们的行政计划将允许我们 实现这些目标

Core 5. Administration of the Center Leadership Vision, Center Theme, and Public Health. Dr. Kost (PI) with US and Thai research teams reported field survey results from Hurricane Katrina and the 2005 tsunami in the American Journal of Clinical Pathology in October 2006 (Kost 2006E). In December 2006 his education brief on POCT and disaster preparedness appeared in Medical Laboratory Observer (Kost 2006F). Observation and awareness of the problems encountered by physicians, nurses, and rescuers inspired the Center theme of critical-emergencv-disaster care. Basically, without suitable or adequate POC and critical care testing devices, health care workers in these world disasters were forced to practice empirical, rather than evidence-based medicine. The POC Technologies Research Network can help correct this situation! Environmental stress testing of POCT began months ago at the POCT'CTR. Results show that POCT reagents will not withstand temperature extremes and other hardships encountered during disaster rescues (see Core 2, "Research Progress Report"). Stephanie Sumner, POCT-CTR researcher, submitted an abstract (Sumner 2007), "Environmental Limits of POCT: Relevance to Disaster Readiness" (see Appendix), to the national meeting of the American Association for Clinical Chemistry (AACC) to be held in San Diego in July 2007. Dr. Kost will moderate and speak in the AACC Symposium, "Diagnostic Health Care Strategies for Critical Care and Disaster Readiness¿Preparing Point-of-Care and Critical Care Testing: The Tsunami, Hurricane Katrina, Earthquakes, and DMATs." His nominee, Dr. Julie Geberding, Head of the CDC, accepted an invitation to speak in the Plenary session prior to his Symposium. These "head start" initiatives and the clinical research on multiplexed pathogen detection described in Core 1 support our Center theme of critical-emergency-disaster care. Early work also has launched the concept of environmental standards for POC devices used in public health. While POCT has evolved to be smaller, smarter, faster, and cheaper, it is not yet robust or connected in rural, emergency, and disaster settings (Kost 2006E and 2006J) and wholeblood multiplexed pathogen detection lags advances in other areas, such as rapid indexed interpretation of multiple cardiac biomarker POCT in acute coronary syndrome for US chest pain centers (Kost 2005B). The mission of our Center, therefore, is to develop fully field-capable POCT, including pathogen detection, with diagnostic results properly interpreted, integrated, and synthesized for rapid medical diagnosis, monitoring, and treatment. Our administrative plan will allow us to achieve these goals