Graduated Recovery Intervention for Early Schizophrenia

描述(由申请人提供)：拟议的研究有以下目标：1)开发和标准化对首发精神分裂症的早期康复敏感的手动个体化治疗(即“渐进式康复干预计划；”GRIP)；2)在一项小规模随机对照试验(RCT)中进行试点测试GRIP，以获得具体的干预参数，包括效果大小、流失率和初步疗效数据；以及3)收集关于干预主持人和调解人的初步数据。为了达到这些目标，我们将分三个阶段进行拟议的研究。在第一阶段，我们将细化和规范握法手册。在第二阶段，我们将对6名患者进行开放、非对照的干预先导试验。在公开试用之后，我们将开发GRIP手册的最终版本。在研究的第三阶段，我们将对患有精神分裂症谱系障碍(即精神分裂症；分裂情感障碍；分裂样障碍)的个体进行一项小型试点随机对照试验，即GRIP(n=25)和支持性咨询(SC；n=25)。参与者将在基线、治疗中期、治疗后和三个月的随访中接受各种结果测量的评估，包括社会功能、物质使用、用药态度和依从性、再次住院和症状。

DESCRIPTION (provided by applicant): The proposed research has the following goals: 1) Develop and standardize a manual-based individual therapy for first-episode (FE) schizophrenia that is sensitive to the early stages of recovery from initial psychosis (i.e., the "Graduated Recovery Intervention Program;" GRIP); 2) Pilot test GRIP in a small-scale randomized controlled trial (RCT) to obtain specific intervention parameters, including effect sizes and attrition rates, as well as preliminary efficacy data; and 3) Collect preliminary data on intervention moderators and mediators. To achieve these goals, we will conduct the proposed research in three stages. During the first stage, we will refine and standardize the GRIP manual. In the second stage, we will conduct an open, uncontrolled pilot test of the intervention on 6 patients. Following the open trial, we will develop a final version of the GRIP manual. In the third phase of the research, we will conduct a small pilot randomized controlled trial of GRIP (n=25) versus supportive counseling (SC; n=25) for individuals with FE schizophrenia spectrum disorders (i.e., schizophrenia; schizoaffective disorder; schizophreniform disorder). Participants will be assessed at baseline, mid-treatment, post-treatment, and three-month follow-up on a variety of outcome measures, including social functioning, substance use, medication attitudes and adherence, rehospitalization, and symptoms.