Coordinating Center for Beta Cell Biology Consortium

此申请是对NOT-DK-04-501的回应，也是范德比尔特大学继续 担任团队科学Beta细胞生物学联盟(BCBC)的协调中心(CC) 自2001年9月以来一直存在的倡议。RFA定义的BCBC的使命 DK-01-014，是为了促进跨学科的方法，以促进我们对胰岛的了解 开发和功能，长期目标是开发一种基于细胞的胰岛素输送疗法。在……里面 BCBC第二阶段，其目标已由RFA DK-04-017和DK-04-018定义为 以及写给范德比尔特的信，BCBC将进行各种调查人员发起的研究，同时 还将重点放在试剂生成活动上。因此，对于这支科学家团队来说，能够 产生新的抗体和转基因小鼠，同时也保持对科学需求的关注 这是决定如何开发一种基于细胞的胰岛素释放疗法的核心，CC一直是 在过去的两年里发展起来的。CC现在完全有能力提供财务、组织和 为BCBC将涵盖的各种科学活动提供信息支持。这个 协调委员会的主要目标是：1)通过组织会议和 务虚会，发布公告，维护一个拥有重要研究资源数据库的网站；2) 通过丰富现有核心设施和开发新的核心设施，支持BCBC内的研究；3) 通过试点和可行性(P&F)补助金计划启动年轻研究人员的新研究；以及4) 通过建立一个合作项目，将不同的科学家群体聚集在BCBC内部 衔接项目。预计通过新的和现有的计划以及 活动，CC将继续鼓励参与的科学家开发新的试剂和策略，以 将成为在贝塔细胞生物学领域进一步发现和进步的平台。

This application is a response to NOT-DK-04-501 and a letter RFA for Vanderbilt University to continue to serve as the Coordinating Center (CC) for the Beta Cell Biology Consortium (BCBC), a team science initiative that has been in existence since September 2001. The mission of the BCBC, as defined by RFA DK-01-014, is to facilitate interdisciplinary approaches that will advance our understanding of pancreatic islet development and function with the long-term goal of developing a cell-based therapy for insulin delivery. In the second phase of the BCBC, whose objectives have been defined by RFAs DK-04-017 and DK-04-018 as well as the letter RFA to Vanderbilt, the BCBC will undertake a variety of investigator-initiated studies while also placing a major emphasis on reagent-generating activities. Thus, for this team of scientists to be able to generate new antibodies and genetically modified mice, while also maintaining focus on the scientific needs that lie at the heart of determining how to develop a cell-based therapy for insulin delivery, a CC has been developed over the past two years. The CC is now fully positioned to provide financial, organizational, and informatic support for the wide variety of scientific activities that will be encompassed by the BCBC. The primary objectives of the CC are to 1) facilitate interactions and communication by organizing meetings and retreats, distributing announcements, and maintaining a website with databases of vital research resources; 2) support research within the BCBC by enriching existing core facilities and developing new cores; 3) to jumpstart new research by young investigators through a Pilot and Feasibility (P&F) Grant Program; and 4) to bring different groups of scientists together within the BCBC by establishing a Program of Collaborative Bridging Projects. It is expected that, through a combination of both new and currently existing programs and activities, the CC will continue to stimulate participating scientists to develop new reagents and strategies that will serve as a platform for further discovery and progress within the beta cell biology field.