Chronic Prostatitis Collaborative Research Network

本申请建议斯坦福大学医学院泌尿系作为 几个国家临床中心之一，共同努力为这项研究开发可行的临床试验 慢性前列腺炎/慢性骨盆疼痛综合征。主要研究者打算作为 设计随机对照临床试验的指导委员会成员，并协助进行 他们与其他国家中心的PL的合作。斯坦福大学的调查小组将在 与进行间质性膀胱炎研究试验的中心平行。同时申请 因为这一努力正在提交。 虽然慢性盆腔疼痛的确切病理生理学和生物学基础，特别是与 泌尿生殖系统功能障碍，尚未阐明，在美国大量的男性继续， 患有这种慢性疾病多年。多模式治疗作为唯一的 管理方法，在很大程度上缺乏合理的科学依据。其具体目的是 项目是利用最有经验和知识渊博的医生的临床经验， 设计治疗方式的临床试验，可以在患者中提供有利的治疗反应。 这类患者的许多亚组。这些试验中的调查将从 制药免费整体治疗方法，代表了最好的想法选择的 参与中心 斯坦福大学集团打算贡献管理慢性 前列腺炎/慢性盆腔疼痛综合征，利用神经行为疗法，并提出了临床试验， 通过渐进式放松练习，有针对性地释放疼痛触发点的物理肌筋膜。 长期以来，人们一直认为患有这种疾病的患者的心理生理学变幻莫测， 但定义不清，值得一个新的面貌与专门的“动手”临床工作进行了几个 研究人员同时进行严格的临床研究设计。

This application proposes that Stanford University School of Medicine, Department of Urology, participate as one of several National Clinical Centers in a cooperative effort to develop feasible clinical trials for the study of chronic prostatitis/chronic pelvic pain syndrome. The Principal Investigator intends to participate fully as a member of the steering committee in designing randomized controlled clinical trials and facilitate carrying them out in collaboration with other national center Pl's. The investigative group at Stanford will work in parallel with the centers conducting trials for investigation of interstitial cystitis. A simultaneous application for that effort is being submitted. While the precise pathophysioiogy and biologic basis of chronic pelvic pain, particularly associated with genitourinary dysfunction, have not been elucidated, a large number of men in the United States continue to suffer immeasuably for many years with this chronic disorder. Multimodal therapy exists as the only management approach and, for the most part, lacks sound scientific justification. The specific aim of this project is to utilize clinical experience from the most experienced and knowledgable physicians available to design clinical trials of treatment modalities that may provide a favorable therapeutic response among the many sub-groups of this population of patients. Investigation within these trials will stretch from pharmaceutical to complimentary holistic treatment methods, representing the best of ideas chosen by the participanting centers. The Stanford Group intends to contribute experience and expertise with regard to managing chronic prostatitis/chronic pelvic pain syndrome utilizing a neurobehavioral therapy and proposes a clinical trial of targeted physiotherapeutic myofascial release of painful trigger points with progressive relaxation exercises. The psychophysiological vagaries among patients suffering from this disorder have long been appreciated, but poorly defined, and deserve a fresh look with a dedicated "hands on" clinical effort conducted by several investigators simultaneously and with rigorous clinical research design..