Signal Processing And Instrumentation Section

信号处理和仪器科(SPIS)为NIH内部研究计划提供电气、电子、光电、计算机和软件工程专业知识，用于需要开发生物医学仪器和信号处理系统的项目。这些SPIS合作涉及先进的信号传输和采集；实时信号和图像处理；以及机器人控制系统。大多数合作的结果是创建新的生物医学仪器技术，包括定制硬件和特定于应用的软件。技术发展和项目的实例包括：cDNA和蛋白质微阵列；组织微阵列；激光捕获显微解剖(LCM)；表达微解剖(XMD)；染色体微解剖；微流体、微加工和微分析；单分子、DNA和染色质纤维机械和操纵；高速扫描光谱分析；原子力显微镜(AFM)；电子顺磁共振(EPR)成像；磁共振成像(MRI)和功能磁共振成像(FMRI)方法和设备；磁共振弹性成像(MRE)成像；超声波成像；正电子发射断层成像(PET)；荧光成像；语音采集和实时自适应处理；用于小鼠疼痛研究的神经元特异性伤害性分析；非人灵长类母婴监测；以及基于视频的自动老鼠活动监测。SPI的这些能力和成就使该集团成为NIH这类工程研究和开发的焦点。该部门的研究和开发活动是与美国国立卫生研究院科学家的合作努力，并经常导致开发独特的、专门的生物医学仪器。其他项目涉及系统模拟和信号分析所需的信号和视频处理算法开发。课程目标要求具备高级模拟和数字电路、生物物理信号传输技术、射频和遥测系统、数字信号处理硬件和软件、可编程逻辑器件、印刷电路板开发、机电器件、光电子学、视频成像以及用于信号处理和控制的计算机仪器的设计专长。

The Signal Processing and Instrumentation Section (SPIS) provides electrical, electronic, electro-optical, computer, and software engineering expertise to the NIH Intramural Research program for projects that require the development of biomedical instrumentation and signal processing systems. These SPIS collaborations involve advanced signal transduction and acquisition; real-time signal and image processing; and robotic control systems. Most collaborations result in the creation of new biomedical instrumentation technologies comprising of custom hardware and application specific software. Example technology developments and projects include: cDNA and protein microarray; tissue microarray; laser capture microdissection (LCM); expression microdissection (xMD); chromosome microdissection; microfluidics, microfabrication, and microanalysis; single molecule, DNA, and chromatin fiber mechanics and manipulation; high-speed scanning spectrometry; atomic force microscopy (AFM); electron paramagnetic resonance (EPR) imaging; magnetic resonance imaging (MRI) and functional MRI (fMRI) methodologies and devices; magnetic resonance elastography (MRE) imaging; ultrasound imaging; positron emission tomography (PET) imaging; fluorescence imaging; speech acquisition and real-time adaptive processing; neuro-specific nociceptive assay for mouse pain studies; nonhuman primate maternal-fetal monitoring; and automated video-based mouse activity monitoring. These SPIS capabilities and accomplishments have established the group as the focal point for this type of engineering research and development at the NIH. The research and development activities of the section are collaborative efforts with NIH Institute scientists, and often result in the development of unique, specialized biomedical instruments. Other projects involve signal and video processing algorithm development required for system simulation and signal analysis. Section goals necessitate design expertise in advanced analog and digital circuitry, biophysical signal transduction techniques, radio-frequency and telemetry systems, digital signal processing hardware and software, programmable logic devices, printed circuit board development, electromechanical devices, opto-electronics, video imaging, and computer based instrumentation for signal processing and control.