Granzymes as regulators of inflammation

炎症过程通常被认为是通过白细胞巨噬细胞的活动启动和维持的。我们建议探索在炎症中被称为颗粒酶的蛋白酶分子的淋巴细胞递送的作用。我们的初步数据已经证明了一种新的范例，通过颗粒酶的活性放大脓毒性休克。我们现在希望在细胞和生化水平上探索这些相互作用，作为更好地理解炎症的一种手段。

Inflammatory processes are normally regarded as being initiated and maintained through the activities of white blood cell macrophages. We propose to explore the role of lymphocyte delivery of protease molecules termed granzymes in inflammation. Our preliminary data has demonstrated a novel paradigm involving amplification of septic shock through the activity of granzymes. We now wish to exlore these interactions at a cellular and biochemical level as a means to better understand inflammation.