EFFECTS OF HIV AND HAART IN AN AGING POPULATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前，美国有超过50万人被诊断患有艾滋病毒/艾滋病，预计在其疾病过程中的某个时候将接受抗逆转录病毒治疗。 随着艾滋病毒流行率因新诊断而上升，以及高效抗逆转录病毒疗法（HAART）死亡率下降，患者的平均年龄和接受治疗的时间将继续增加。 因此，不仅对HAART相关并发症的长期管理，而且对老年艾滋病毒感染者中发病率较高的非艾滋病毒病因的诊断和管理，都是一个更大的公共卫生问题。 这项研究将提供机会，以评估50岁及以上的HIV感染患者的药物毒性，合并症，以及肾，肝，内分泌，血液学和认知功能异常的患病率。 此外，还将对骨矿物质密度（BMD）、HAART反应性和心血管风险进行评估。 随后将实验室检查值、BMD、认知测试评分、合并症和心血管风险因素的患病率与来自国家健康和检查调查（NHANES）的未感染HIV的人进行比较。 来自国家健康和营养调查系统的数据文件可在互联网上免费提供，供公众使用。 这项研究提供的数据不仅对提高护理提供者对感染艾滋病毒的老年人重要健康问题的了解和认识非常宝贵，而且还有助于确定感染艾滋病毒的老年人和未感染艾滋病毒的老年人在接受有效抗逆转录病毒治疗方面的重大差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently over 500,000 persons in the U.S. have been diagnosed with HIV/AIDS and can be expected to be on antiretroviral therapy at some point during the course of their disease. As the prevalence of HIV rises due to new diagnoses and declining mortality rates on highly active antiretroviral therapy (HAART), average patients' age and length of time on therapy will continue to increase. There is thus a greater public health concern not only for the long-term management of HAART-related complications but also for the diagnosis and management of non-HIV causes of morbidity which may have a higher prevalence in older HIV-infected persons. This study will provide the opportunity to evaluate HIV-infected patients age 50 and over for prevalence of medication toxicities, comorbidities, and abnormalities in renal, hepatic, and endocrine, hematologic, and cognitive function. Additionally assessments will be made with regard to bone mineral density (BMD), responsiveness to HAART, and cardiovascular risk. Laboratory values, BMD, cognitive test scores, and prevalence of comorbidities and cardiovascular risk factos will subsequently be compare to HIV-uninfected persons from the National Health and Examination Survey (NHANES). Data files from NHANES are freely available on the internet for the public's use. The data provided by this study will not only be invaluable in increasing care providers' knowledge and awareness of important health issues in older HIV-infected individuals, but will also serve to determine the significant differences between older HIV-infected and non-infected persons in the setting of effective antiretroviral therapy.