EATRIGHT FOLLOW UP STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料：这项试点和可行性研究目前正在进行中，由UAB临床营养研究中心（CNRC）资助，利用观察性队列设计来确定至少1年前完成该计划的前EatRight参与者的长期减肥成功率。这项研究的主要目的是确定EatRight在最后一次参与日期为1-4年前的人中的长期有效性;次要目的是了解水果和蔬菜摄入量对体重维持的影响以及减肥维持对疾病风险因素的影响。 研究问题：我们假设，在12周的EatRight干预期间，体重、腰围和BMI的变化将保持在95%的置信区间（CI）内。40%的人在干预后1至4年随访。次要假设指出，与一组匹配的对照组相比，那些保持50%体重减轻的人将有更高的水果和蔬菜摄入量，并更好地控制标准心血管和代谢疾病风险因素。迄今为止，75名前EatRight参与者已经评估了代谢疾病风险，身体成分和饮食摄入量的标志物。 GCRC利用率：本GCRC应用程序的目的是支持将对照队列添加到研究人群中，从而允许随时间推移比较结局。 研究人群：对照组参与者将根据年龄、性别、体重和身高与当前EatRight随访研究参与者相匹配。 结果测量：对照组参与者将接受与前EatRight参与者相同的测量，包括体重，血压，血脂，葡萄糖，胰岛素，双能X射线吸收测定法的身体成分，以及4天食物记录的饮食摄入分析。两个队列都将接受随访，

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: This pilot and feasibility study, currently underway and funded by the UAB Clinical Nutrition Research Center (CNRC), utilizes an observational cohort design to determine the long-term weight loss success of former EatRight participants who completed the program at least 1 year ago. The primary aim of this study is to determine the long-term effectiveness of EatRight in those whose last date of participation was 1-4 years ago; secondary aims are to understand the impact of fruit and vegetable intake on weight maintenance and the impact of weight loss maintenance on disease risk factors. Study question: We hypothesize that changes in weight, waist circumference and BMI during the 12-week EatRight intervention will be maintained within a 95% confidence interval (CI) of ? 40% of individuals at follow-up 1 to 4 years post-intervention. Secondary hypotheses state that, compared to a group of matched controls, those with maintenance of 50% of weight loss will have higher fruit and vegetable intake and better control of standard cardiovascular and metabolic disease risk factors. To date, 75 former EatRight participants have been assessed with markers of metabolic disease risk, body composition, and dietary intake. GCRC utilization: The purpose of this GCRC application is to support the addition of a control cohort to the study population, thereby allowing comparison of the outcomes over time. Study population: Control participants will be matched to current EatRight follow-up study participants by age, gender, weight, and height. Outcome measures: Control participants will receive the same measures as former EatRight participants, including weight, blood pressure, lipids, glucose, insulin, body composition with dual energy X-ray absorptiometry, and analysis of dietary intake from 4-day food records. Both cohorts will be followed longitudi