MOLECULAR GENETIC MARKERS IN PRIMATE DISEASE MODELS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。非人灵长类动物是生物医学研究的重要组成部分，作为许多人类疾病的动物模型。增加非人类灵长类动物模型的遗传信息将扩大疾病相关研究的机会。随着灵长类动物遗传特征的进展，未来使用这些物种的研究项目将能够更充分地研究遗传与疾病之间的关系。该项目的第一个目标是在现有的狒狒遗传连锁图谱中添加新的遗传多态性。第二个目标是鉴定恒河猴的额外遗传多态性，并将它们添加到恒河猴连锁图谱中。我们已经确定了新的遗传标记来填补狒狒连锁图谱中几个现有的空白。该项目将提高狒狒和恒河猴在与心脏病、肥胖、精神疾病、骨质疏松症和包括艾滋病在内的传染病有关的各种疾病研究中的价值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonhuman primates are a critical component of biomedical research, as animal models for many human diseases. Increased genetic information about nonhuman primate animal models will expand opportunities for disease-related research. As the genetic characterization of primates progresses, future research projects using these species will be able to more fully investigate relationships between genetics and disease. The first objective of this project is to add new genetic polymorphisms to the existing baboon genetic linkage map. The second objective is to identify additional genetic polymorphisms in rhesus monkeys and add them to the rhesus linkage map. We have identified new genetic markers to fill several existing gaps in the baboon linkage map. This project will improve the value of baboons and rhesus for a wide variety of disease studies related to heart disease, obesity, psychiatric disorders, osteoporosis and infectious disease, including AIDS.