ANKYRIN-B SYNDROME

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们正在描述小鼠的杂合性，因为锚蛋白b的零突变。这些动物是可以生存的，但寿命较短。我们需要评估这些小鼠体内的许多组织以及可能的肿瘤。观察整个动物并保存三维信息的一种非常有效的方法是对固定的动物进行核磁共振扫描，随后可以通过常规组织学进行评估。我们将在3个月和12个月大的小鼠（对照和杂合子）中具体评估以下指标：大脑、肾脏、胸腺和脾脏的大小；可能的扩张型心肌病；可能的肿瘤/质量。仅从常规组织学上是不可能获得这种水平的分析的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are characterizing mice heterozygous for a null mutation in ankyrin-B. These animals are viable, but have a reduced life span. We need to evaluate a number of tissues as well possible tumors in these mice. A very efficient way to look at the whole animal and preserve three-dimensional information would be to MRI scan a fixed animal that could subsequently be evaluated by conventional histology. We will specifically evaluate the following in 3-month and 12-month-old mice (control and heterozygotes): the size of the brain, kidney, thymus, and spleen; possible dilated cardiomyopathy; possible tumors/masses. It would be impossible to obtain this level of analysis from conventional histology alone.