CONTRIBUTIONS OF PERIPHERAL AND CENTRAL AIRWAYS TO AIRFLOW OBSTRUCTION IN ANIMA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。哮喘是一种慢性疾病，困扰着全世界数百万人。在过去的二十年里，哮喘的发病率和死亡率都在增加。哮喘最典型的特征之一是气道高反应性，其由过度的气道狭窄和伴随的气流阻塞引起。为了更好地理解人类气道高反应性的机制，在疾病的动物模型中确定外周和中央气道对气流阻塞的各自贡献是重要的。目前，通过测量全肺阻力和/或顺应性来评估气道反应性。因此，没有直接的技术可以确定外周气道与中央气道的阻力或顺应性的变化。 这些影像学研究将量化哮喘小鼠模型中外周气道对气流阻塞的贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a chronic disease afflicting millions of people worldwide. The morbidity and mortality assocaited with asthma have increased over the past two decades. One of the most debilitating and classic features of asthma, airway hyperresponsiveness, results from excessive airway narrowing and concomitant airflow obstruction. To better understand the mechanisms underlying airway hyperresponsiveness in humans it is important to determine the respective contributions of peripheral and central airways to airflow obstruction in animal models of the disease. Currently, airway responsiveness is assessed by measuring whole lung resistance and/or compliance. Thus, there is no direct technique by which changes in resistance or compliance of peripheral vs central airways can be determined. These imaging studies would quantitate the contribution of peripheral airways to airflow obstruction in a mouse model of asthma.