NANOSCALE FLUCTUATIONS OF ERYTHROCYTE SUBDOMAINS IMAGED BY FOURIER PHASE MICROS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。傅里叶相位显微术（FPM）是一种新型的成像技术，其提供关于动态生物样品的光程长度偏移的定量信息，具有亚纳米级的灵敏度，在延长的时间段内。FPM用于测量在从几秒到几小时的时间间隔期间与活红细胞膜相关的纳米级波动。实验结果表明，存在的动态子域内的细胞，表现出在不同的频率振荡。这些波动的非随机性表明，它们是由与这个生命系统相关的确定性现象驱动的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fourier Phase Microscopy (FPM) is a novel imaging technique that provides quantitative information about the optical path-length shifts through dynamic biological samples with sub-nanometer sensitivity over extended periods of time. FPM was used to measure nanoscale fluctuations associated with the membrane of live erythrocytes during time intervals ranging from a few seconds to hours. The experimental results demonstrate the existence of dynamic subdomains within the cell, which exhibit oscillations at various frequencies. The non-random nature of these fluctuations suggests that they are driven by deterministic phenomena associated with this living system.