NON-CONTACT CHARACTERIZATION OF RED BLOOD CELL MECHANICAL PROPERTIES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。希尔伯特相显微镜（HPM）是我们实验室开发的一种新型成像技术，能够以完全无创的方式提供纳米级和毫秒级红细胞波动的定量信息。我们开发了一种数学算法，可以从空间分解的均方波动中提取物理参数，如膜弯曲模量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hilbert phase microscopy (HPM) is a novel imaging technique developed in our lab that is capable of providing quantitative information about the red blood cells fluctuations at the nanometer and millisecond level, in a completely non-invasive manner. We developed a mathematical algorithm which allows extracting physical parameters, such as the membrane bending modulus, from the spatially resolved mean squared fluctuations.