PROTEINS UNDER PRESSURE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。黄嘌呤是一种黄色荧光蛋白，在压力下会改变颜色。当加压至2kbar时，其发射光谱红移约4nm。量子化学模型表明，这可能是由于蛋白质中的发光元素在压力下变形所致。有了晶体学数据，我希望通过量子力学，把蛋白质的结构和它的功能、它的颜色联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Citrine is a yellow fluorescent protein that changes color under pressure. Its emission spectrum redshifts by around 4 nm when it is pressurized to 2 kBar. Quantum chemical modelling indicates that this might be due to deformation of the light emitting element in the protein by pressure. With crystallographic data, I hope to link the structure of the protein to its function, its color, through quantum mechanics.