MONTE CARLO ALGORITHM FOR VIRUS PARTICLE RECONSTRUCTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。SAVR软件包被开发用于二十面体病毒颗粒重构。该软件已成功地解决了几个病毒粒子结构的亚纳米分辨率。正在不断改进，使其更加健全和普遍。我们正在探索使用蒙特卡罗算法来提高粒子方向搜索和细化的效率和准确性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SAVR software package was developed for icosahedral virus particle reconstruction. This software has sucessfully solved several virus particle structures to sub-nanometer resolution. Continuous improvements are being made to make it more robust and universal. We are exploring the use of Monte Carlo algorithm to improve the efficiency and accuracy of the particle orientation search and refinement.