LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目由NIGMS胶水基金支持。整个程序有以下目标：(1)分离和检测特定细胞中的所有脂质，并发现和表征可能存在的任何新脂质。(2)定量测定存在的每一种脂质代谢物，定量测定它们在细胞功能过程中水平和位置的变化。(3)定义每种脂质的生化途径，并开发确定相互作用网络的脂质图。为了帮助中性脂核心，脂组学重点领域，由科罗拉多大学健康科学中心的R.C. Murphy指导，BUSM MS资源将协助新型中性脂的结构测定。C. E. Costello为脂质MAPS项目提供了质谱分析新方法方面的专业知识

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is supported by an NIGMS Glue Grant. The overall program has the following objectives: (1) Separate and detect all of the lipids in a specific cell and discover and characterize any novel lipids that may be present. (2) Quantitate each of the lipid metabolites present and quantitate the changes in their levels and location during cellular function. (3) Define the biochemical pathways for each lipid and develop lipid maps which define the interaction networks. To aid the Neutral Lipids Core, Lipidomics Focus Area, directed by R.C. Murphy, Univ. Colorado Health Sciences Center, the BUSM MS Resource will assist in the structural determinations of novel neutral lipids. C. E. Costello provides expertise on new methods for mass spectral analysis of lipids to the Lipid MAPS program