Incident AD in Mexican Americans: Feasibility Study

描述（由申请人提供）：这是R21申请的第二次重新提交，旨在调查在芝加哥墨西哥裔西班牙裔和非西班牙裔居民社区开展基于人群的阿尔茨海默病发生率研究的可行性。阿尔茨海默病是一种常见的无法治愈的疾病，很少有确定的危险因素被确定。墨西哥裔西班牙人是美国人口最多、增长最快的少数民族，他们的疾病和风险因素的患病率很高，可能使他们患阿尔茨海默病的风险增加。拟议的调查小组拥有独特的技能、经验和资源，可以对偶发性阿尔茨海默病进行社区研究。然而，开展这类研究面临重大挑战，包括：1)墨西哥裔美国人的年龄相对较年轻，导致检测阿尔茨海默病病例的成本可能很高；2)由于语言、文化和移民差异，墨西哥社区在社会和地理上处于孤立状态，无法对老年居民进行全面统计，以计算患病率和发病率。拟议的研究将提供必要的试点数据和社区发展，以调查在地理上确定的芝加哥社区进行阿尔茨海默病风险因素研究的可行性。为了实现这些目标，拟议的研究将：1)分析美国人口普查数据，以确定最适合研究的芝加哥社区；2)进一步争取社区对研究的支持；3)试点基于信息的芝加哥老年居民普查，并评估其与美国人口普查数据的完整性。拟议的研究将提供必要的试点数据和社区发展，以调查在芝加哥墨西哥裔西班牙裔社区进行老年人口完整枚举的可行性，以进行阿尔茨海默病和认知能力下降的纵向研究。

DESCRIPTION (provided by applicant): This is the second resubmission of an R21 application to investigate the feasibility of conducting a population-based study of incident Alzheimer's disease in a Chicago community of Mexican Hispanic and non-Hispanic residents. Alzheimer's disease is a common and incurable disease for which few established risk factors have been identified. The Mexican Hispanic population, which is the largest and fastest growing ethnic minority in the US, has a high prevalence of conditions and risk factors that may place them at increased risk of Alzheimer's disease. The proposed investigative team possesses unique skills, experience, and resources to conduct community studies of incident Alzheimer's disease. However, there are significant challenges to conducting this type of study, including: 1) the relatively young age of the Mexican American population, resulting in potentially high costs of detecting Alzheimer's disease cases, and 2) social and geographical isolation of the Mexican community due to language, cultural and immigration differences, preventing full enumeration of older residents for the computation of prevalence and incidence rates. The proposed study will provide the necessary pilot data and community development to investigate the feasibility of conducting a risk-factor study of Alzheimer's disease in a geographically- defined Chicago community. To accomplish these goals the proposed study will: 1) analyze U.S. Census data to identify the Chicago communities best suited for the study, 2) further engage community support for the study, and 3) pilot an informant-based census of older Chicago residents and assess its completeness compared with U.S. census data. The proposed study will provide the necessary pilot data and community development to investigate the feasibility of conducting a complete enumeration of the older population for a longitudinal study of Alzheimer's disease and cognitive decline in a Chicago Mexican Hispanic community.