ATOMIC RESOLUTION STRUCTURE OF THE INTACT BACTERIAL RIBOSOME

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们最近获得了完整细菌核糖体的晶体，它能衍射超过3.9埃的x射线。这些晶体有可能衍射到原子分辨率（3埃）。完整细菌核糖体的原子分辨率结构将是生物学上的一个突破性成果，并将影响我们对蛋白质合成和许多抗菌剂功能的一般理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have recently obtained crystals of the intact bacterial ribosome that diffract x-rays beyond 3.9 Angstroms. It is possible that these crystals could diffract to atomic resolution (3 Angstroms). The atomic resolution structure of the intact bacterial ribosome will be a groundbreaking result in biology, and will impact our general understanding of protein synthesis and the function of numerous antimicrobial agents.