THE ROLE OF FORMATION OF SOLUBLE OLIGOMERS IN THE GROWTH OF AMYLOID FIBRILS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。淀粉样蛋白纤维沉积物的形成发生在许多疾病中，并且似乎也作为酵母中表型的某些表观遗传变化的自然原因而发生。有证据表明，淀粉样蛋白的形成似乎是多肽链的共性，这表明，识别参与寡聚化的蛋白质序列中特定位置的能力将允许对淀粉样蛋白形成的潜在机制进行更深入的分析，这在很大范围的背景下是令人感兴趣的，包括对人类健康的重大影响，如阿尔茨海默病和帕金森病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation of amyloid fibrilar deposits occurs in a number of diseases and also appears to occur as a natural cause of certain epi-genetic changes of phenotype in yeast. Evidence that formation of amyloid seems to be generic to polypeptide chains suggests that the ability to identify specific positions in a protein sequence involved in oligomerization will allow a closer analysis of the underlying mechanism for amyloid formation in general, which is of interest in a large range of contexts, including major impacts on human health such as Alzheimer's and Parkinson's diseases.