FLUTAMIDE TREATMENT OF PREMENSTRUAL DYSPHORIC DISORDER

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的主要目的是确定雄激素受体拮抗剂氟他胺阻断雄激素受体是否会缓解经前烦躁不安障碍的症状。将进行一项安慰剂对照、平行设计的初步研究。将招募64名受试者，这将允许检测氟他胺治疗的大效应，并提供数据来估计较小的效应量，以便在需要时用于设计更大规模的研究。氟他胺治疗的耐受性也将通过比较氟他胺和安慰剂治疗之间的副作用来估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this study is to determine whether androgen receptor blockade using the androgen receptor antagonist flutamide will relieve symptoms of premenstrual dysphoric disorder. A placebo controlled, parallel design pilot study will be conducted. 64 subjects will be recruited, which will allow detection of a large effect of flutamide treatment, and provide data to estimate smaller effect sizes for use in design of a larger-scale study, if indicated. Tolerability of flutamide treatment will also be estimated by comparison of side effects between flutamide and placebo treatment.