IMMUNE CORRELATES OF COGNITIVE FUNCTION IN SLE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究旨在探讨系统性红斑狼疮（SLE）患者血液中的免疫措施。具体而言，本研究将寻找血液中不同免疫标记物与SLE患者和正常对照参与者的认知障碍和记忆障碍类型之间的潜在关系。作为母研究的一部分，SLE患者和正常对照者将接受神经心理学测试，以确定SLE患者的特定认知障碍。这项补充研究将包括从完成父母研究指定的神经心理测试的参与者中抽取一次血液。测量血液中特定的免疫参数不仅可以提供与正常对照相比与SLE相关的生物标志物，还可以识别SLE中认知功能的潜在免疫介质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is exploring immune measures in the blood of persons with systemic lupus erythematosus (SLE; Lupus). Specifically, this study will be looking for potential relationships between different immune markers in the blood and types of cognitive impairments and memory impairments in persons with SLE and normal control participants. As a part of the parent study, participants with SLE and normal control subjects will undergo neuropsychological testing that will identify particular cognitive impairments in SLE. This supplementary study will include a single blood draw from participants completing the neuropsychological testing appointment of the parent study. The measurement of particular immune parameters in the blood will not only provide insight into the biological markers that are related to SLE compared with normal controls, but will allow for the identification of potential immune mediators of cognitive function in SLE.