CORONARY ARTERY CALCIFICATION IN TYPE I DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。冠状动脉疾病（CAD）是导致I型糖尿病患者死亡的主要原因。CAD也发生在生命早期，影响女性和男性一样多，相关死亡率显著高于一般人群。本研究将重点研究非侵入性检测1型糖尿病高危人群的冠心病，用于未来的筛查和预防计划。将从丹佛都会区招募800名I型糖尿病患者和600名非糖尿病患者作为对照。人口分布近似于全国和丹佛地区的1型糖尿病人口统计数据。这项研究将招募大约49%的男性和51%的女性受试者；预期种族分布为白人87%，西班牙裔7%，黑人3%，其他3%。要参加这项研究，所有受试者必须在20至55岁之间。1型糖尿病患者必须患有糖尿病至少10年，必须在30岁之前被诊断出患有糖尿病，并且必须在被诊断出患有糖尿病的一年内使用胰岛素。糖尿病患者和非糖尿病患者都将进行首次临床访问。在这次访问中，患者将被问及他们的医学背景。测量体重、身高、腰围、臀围和血压。心电图（ECG）、尿液样本和血液样本也将获得。糖尿病患者将被要求在3年内再来一次门诊。患者还将被安排进行电子束计算机断层扫描（EBCT），这将寻找心脏冠状动脉钙化。同时对腹部进行扫描，以测量腹部的脂肪量。计算冠状动脉钙化（CAC）评分和左心室面积（LV）。CAC和大左室面积可能是CAD的早期征象。所有患者将被要求在3年内再次进行EBCT检查。在一项亚研究中，50名高风险糖尿病患者（CAC评分约为100），30名低风险糖尿病患者（CAC评分低于100）和20名对照患者将进行额外的访问。这次访问将包括休息/压力测试，观察休息和最大运动（使用跑步机）时的心脏血流。在这两种情况下都将使用造影剂来确定心脏的血流。糖尿病患者将被要求在3年内重复休息/压力测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Coronary artery disease (CAD) is the main cause of death in person with Type I diabetes. CAD also occurs earlier in life, affects women as often as men, and associated mortality is dramatically higher than that in the general population. This study will focus on non-invasive detection of CAD in high-risk persons with Type I diabetes for application in future screening and prevention programs. A sample of 800 patients with Type I diabetes and 600 non-diabetic controls will be recruited from the Denver Metro Area. The population distribution approximates the national and Denver area demographics for Type I diabetes. This study will recruit approximately 49% male and 51% female subjects; the expected ethnic distribution is 87% white, 7% Hispanic, 3% black, and 3% other. To enroll in the study, all subjects must be between 20 and 55 years of age. Patients with type I diabetes must have had diabetes for at least 10 years, must have been diagnosed before the age of 30, and must have had insulin within one year of being diagnosed. Both diabetic and non-diabetic patients will come for an initial clinic visit. At this visit, patients will be asked about their medical background. Measurements of weight, height, waist and hip circumference, and blood pressure will be taken. An electrocardiogram (ECG), a urine sample and blood sample will also be obtained. Diabetic patients will be asked to come in for another clinic visit in 3-years. Patients will also be scheduled for an electron-beam computed tomography scan (EBCT), which will look for coronary artery calcification in the heart. A scan of the abdomen will be done at the same time to measure the amount of fat in the abdomen. A coronary artery calcification (CAC) score and left ventricular area (LV area) will be calculated. CAC and large LV area may be early signs of CAD. All patients will be asked to have a repeat EBCT in 3 years. In a substudy, 50 high-risk diabetics (CAC score about 100), 30 low-risk diabetics (CAC score below 100), and 20 controls will come in for an additional visit. This visit will consist of a rest/stress test, which looks at heart blood flow at rest and during maximal exercise (using a treadmill). A contrast dye will be used in both cases to determine the blood flow in the heart. Patients with diabetes will be asked to repeat the rest/stress test in 3-years.