CORRELATIVE STUDIES ON ANGIOGENESIS AND LYMPHANGIOGENESIS IN BREAST CANCER

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。血管生成是支持肿瘤生存所必需的，因为它允许持续的氧气供应和有毒废物的清除。促血管生成因子刺激恶性状态下的血管增殖，促进肿瘤的生长和转移。然而，特定的血管内皮生长因子(VEGFs)亚型在肿瘤进展中的作用尚不清楚，并可能为淋巴侵袭和转移扩散的方法提供深入的了解。此外，从骨髓中招募内皮祖细胞有助于血管生成和淋巴管生成的直接形成，循环造血细胞的定量可能提供有关肿瘤进展方式的信息。这项先导性研究旨在验证乳腺癌血管生成的分子、细胞和功能替代标记物，确定新的治疗和预后靶点，并将血管生成标记物与乳腺癌患者的分期和预后联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Angiogenesis is necessary to support neoplastic survival since it allows for continuous oxygen supply and toxic waste removal. Proangiogenic factors stimulate vascular proliferation in malignant states and contribution to tumor growth and metastasis. However, the role of specific vascular endothelial growth factors (VEGFs) isoforms in tumor progression is widely unknown and may provide insight into the method of lymphatic invasion and metastatic spread. In addition, recruitment of endothelial progenitor cells from the bone marrow contributes to the direct formation of angiogenic and lymphangiogenic vessels, and quantification of circulating hematopoietic cells may offer information about the method of tumor progression. This pilot study was designed to validate molecular, cellular, and functional surrogate markers of angiogenesis in breast cancer, identify new therapeutic and prognostic targets, and to correlate angiogenesis markers to stage and prognosis in patients with malignant breast disease.