CARDIAC MEMORY AND DIASTOLIC FUNCTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在这项研究中，我们建议评估左心室收缩功能异常受试者心室起搏后舒张功能的改变。我们将把这与心电图的变化和通过血浆儿茶酚胺测量的自主神经张力联系起来。四组受试者，每组10例植入心脏起搏器，将使用放射性核素血管造影来评估舒张功能。各组包括：1)左心室收缩功能正常；2)缺血性心肌病；3)非缺血性心肌病；4)肥厚性心肌病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study we propose to evaluate the alterations in diastolic function following ventricular pacing in subjects with abnormal left ventricular systolic function. We will relate this to changes in the electrocardiogram and to autonomic tone as measured by plasma catecholamines. Four subject groups, consisting of ten patients each with implanted pacemakers, will be evaluated using radionuclide angiography to characterize diastolic function. The groups will include subjects with 1) normal left ventricular systolic function, 2) ischemic cardiomyopathy, 3) nonischemic cardiomyopathy, and 4) hypertrophic cardiomyopathy.