ROLE OF CYTOCHROME P450 3A5 GENOTYPE UPON FLUCONAZOLE/MIDAZOLAM

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的目的是调查不同版本的基因的功能，负责产生一种特殊的酶，称为细胞色素P450 3A 5（CYP 3A 5）。我们将研究不同基因版本对两种药物（咪达唑仑和红霉素）代谢的影响。我们还将研究不同基因版本对药物氟康唑对咪达唑仑和红霉素代谢的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to investigate the function of different versions of a gene responsible for producing a particular enzyme, called cytochrome P450 3A5 (CYP3A5). We will study the effect of the different gene versions upon the metabolism of two medications, midazolam and erythromycin. We will also study the influence of the different gene versions upon the effect that the medication fluconazole has upon the metabolism of midazolam and erythromycin.