ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这是一项非随机自然史非治疗研究，将在美国和加拿大的约50个研究中心招募共计800例受试者，包括200例正常对照、400例轻度认知障碍个体和200例轻度阿尔茨海默病（AD）受试者，进行纵向随访。这项研究旨在研究成像研究和生物标志物测试的有用性，以及记忆，思维和日常功能的测量，在未来的研究中，重点是早期识别和治疗阿尔茨海默病。本研究旨在为这些类型的未来研究提供数据存储。对于这个项目，我们将招募总共20名受试者，如下所示：这项研究将观察三组不同的志愿者：1）正常对照组：没有明显记忆问题的志愿者，将被研究36个月。2）轻度认知障碍（MCI）组：具有轻度记忆问题的志愿者，如通过一系列记忆和认知测试的分数所确定的，（在本研究中称为“轻度认知障碍”- MCI），其将被研究36个月。将招募8名受试者3）阿尔茨海默病组：将研究24个月的轻度阿尔茨海默病志愿者。将招募4名受试者，并有4名研究伙伴陪同。所有受试者必须有一个人（配偶、朋友或亲戚），称为“研究伴侣”，愿意：陪同受试者参加所有研究访视，并告知受试者在本研究期间的健康状况变化。 所有受试者将每年进行神经心理学测试和1.5特斯拉的脑部MRI。一个受试者子集（N = 4）将接受2次腰椎穿刺（基线和1年），另一个受试者子集将在后续访视时接受3 T MRI扫描。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a non-randomized natural history non-treatment study in which a total of 800 subjects including 200 normal controls, 400 individuals with mild cognitive impairment, and 200 subjects with mild Alzheimer's Disease (AD) will be recruited at approximately fifty sites in the United States and Canada for longitudinal follow up. This research study is designed to look at the usefulness of imaging studies and biomarker tests, together with measurements of memory, thinking and daily functioning, in the future conduct of studies that will focus on the identification and treatment of Alzheimer's disease at an early stage. This study aims to produce data to be stored for these kinds of future research studies. For this project we will be recruiting at total of 20 subjects as listed below: This study will look at three different groups of volunteers: 1) Normal Control group: Volunteers with no apparent memory problems that will be studied for 36 months. Four subjects from this group will be recruited 2) Mild Cognitive Impairment (MCI) Group: volunteers with mild memory problems as determined by a series of scores on memory and cognitive tests, (referred to in this study as "mild cognitive impairment" - MCI) that will be studied for 36 months. Eight subjects will be recruited 3) Alzheimer's disease group: volunteers with mild Alzheimer's disease that will be studied for 24 months. Four subjects will be recruited, and four study partners to accompany them. All Participants must have an individual (spouse, friend, or relative), called a "study partner," who is willing to: accompany participants to all of the study visits and communicate changes in participant's health status over the period of this study. All subjects will have neuropsychological testing annually and a 1.5 Tesla brain MRI. A subset of subjects (N = 4) will receive 2 lumbar punctures (baseline and one year) and another subset of subjects will get a 3T MRI scan at a subsequent visit.