The RNA polymerase bridge helix and domain communication

细胞生长、存活和存活的许多活动都依赖于显示小机器特性的分子。获取DNA信息的方式依赖于一种叫做RNA聚合酶的机器。虽然我们知道RNA聚合酶的形状和形式，但它的各个部分是如何协同工作的还远不清楚。我们将使用一个研究项目来研究其中一个被称为桥螺旋的部分是如何使RNA聚合酶能够有效地与DNA相互作用的。由于RNA聚合酶从人类到细菌都是保守的，因此这项工作具有重要的基础意义，特别是对一些有害细菌的管理需要一种基于知识的方法。

Many activities allow cells to grow, remain alive and viable rely on molecules displaying the properties of small machines. The way in which informaton in DNA is accessed relies on one such machine, called RNA polymerase. Although we know the shape and form of RNA polymerase, quite how its parts work together is far less clear. We will be using a program of research to work out how one part-called the Bridge Helix -contributes to RNA polymerase being able to productively interact with DNA. Because RNA polymerases are conserved from man to bacteria, the work is of fundamental importance, and especialy for a knowledge based approach needed for the management of some harmful bacteria.