ALZHEIMER'S DISEASE GENETICS INITIATIVE: THE MULTIPLEX FAMILY STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。NIA遗传学倡议：多重家庭研究的目的是确定有多个成员被诊断为晚发性阿尔茨海默病的家庭。将对家族进行临床鉴定，并收集血液样本以建立细胞系。如果没有血液样本，将收集尸检样本进行DNA提取和储存。我们的目标是在三年内招募1000个家庭。来自这些家庭的临床和人口统计数据将在当地收集，编码数据（没有标识符）将被发送并纳入阿尔茨海默病家庭的国家数据库。该数据库连同生物样本将被存放在印第安纳大学的阿尔茨海默病国家细胞储存库（NCRAD）。来自这些家庭的生物样本和数据将提供给合格的研究人员，他们必须在获得DNA和数据之前签署一份材料转移协议。一个被称为细胞库咨询委员会（CBAC）的监督委员会将审查和监测家庭识别和登记、数据收集、建立细胞系和获取样本的过程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the NIA Genetics Initiative: Multiplex Family Study is to identify families with multiple members diagnosed with late-onset Alzheimer's Disease. Families will be characterized clinically and blood samples will be collected to establish cell lines. If a blood sample is not available, autopsy samples will be collected for DNA extraction and storage. Our goal is to recruit 1,000 families in three years. Clinical and demographic data from these families will be collected at the local site and coded data, without identifiers, will be sent and included in a national database of families with Alzheimer's Disease. This database, along with biological samples, will be housed at the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University. The biological samples and data from these families will be available to qualified researchers, who must sign a Material Transfer Agreement before receiving DNA and data. An oversight committee knows as the Cell Bank Advisory Committee (CBAC) will review and monitor the process of family identification and enrollment, data collection, the establishment of cell lines and access to samples.