ACTG A5079 PHYSIOLOGIC TESTOSTERONE SUPPLEMENTATION IN HIV

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。检验以下假设：在血清睾酮水平轻度至中度降低的HIV阳性腹型肥胖男性中，睾酮替代治疗组内脏脂肪横截面积从基线至24周的变化大于安慰剂组。评估这种治疗的安全性和耐受性。评价睾酮替代治疗对脂质代谢的影响。通过DEXA和CT评估局部脂肪。评估睾酮替代对瘦体重的影响。评价对腰臀比、腹围的影响，评价对生活质量和体像的影响，评价睾酮替代效果的48周持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test the hypothesis that the change in visceral fat cross-sectional area from baseline to 24 weeks will be greater with testosterone replacement than with placebo in HIV-positive men with abdominal obesity who have mildly to moderately reduced serum testosterone levels. Evaluate the safety and tolerability of this treatment. Evaluate the effect of testosterone replacement on lipid metabolism. Assess regional fat by DEXA and CT. Evaluate the effect of testosterone replacement on lean body mass. Evaluate the effect on waist-to-hip ratio and abdominal circumfrance, evaluate effect on quality of life and body image, and evaluate the 48 week durability of the effect of testosterone replacement.