BONE DENSITY IN HIV-INFECTED WOMEN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。确定HAART时代的健康艾滋病毒感染妇女群体是否表现出比预期更高的骨量减少和骨质疏松症患病率。确定这一人群中骨量减少和骨质疏松的风险因素，确定蛋白酶抑制剂的使用和身体成分变化(脂营养不良)是否像以前在艾滋病毒阳性男性中记录的那样导致艾滋病毒感染妇女骨密度降低，并通过分析炎症细胞因子和骨转换标记物来确定艾滋病毒感染妇女骨量减少的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine whether the population of healthy HIV-infected women in the era of HAART exhibits a higher than expected prevalence of osteopenia and osteoporosis. Identify risk factors of osteopenia and osteoporosis in this population, determine whether protease inhibitor use and body composition changes (lipodystrophy) contribute to reduced bone density in HIV-infected women as has previously been documented in HIV-positive men and identify mechanisms of osteopenia in HIV-infected women via analysis of inflammatory cytokines and bone turnover markers.