DOES MELATONIN REDUCE URINARY CALCIUM IN HYPERCALCIURIC STONE-FORMERS?

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项先导性研究的具体目的是：1)确定褪黑素是否能降低服用指导和/或持续代谢饮食的高钙尿性结石患者的尿钙，以及这种作用是否随着停药而消失。2)探讨褪黑激素对高钙尿型结石患者进食指导和/或恒定代谢饮食的降钙尿作用的可能机制(肠道钙吸收、骨吸收、骨形成和/或肾钙重吸收的改变)。3)探讨褪黑素治疗期间及停药后对肾结石危险因素的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this pilot study are: 1) to determine if melatonin lowers urinary calcium in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet and if this effect is lost with discontinuation. 2) to explore the possible mechanism (change in intestinal calcium absorption, bone resorption, bone formation, and/or renal calcium reabsorption) of hypocalciuric effect of a melatonin in hypercalciuric stone-formers consuming instructed and/or constant metabolic diet. 3) to determine the effect of melatonin on kidney stone risk factors during treatment and after discontinuation of melatonin.